PMID- 1318053
OWN - NLM
STAT- MEDLINE
DCOM- 19920716
LR  - 20190509
IS  - 0895-7061 (Print)
IS  - 0895-7061 (Linking)
VI  - 5
IP  - 4 Pt 1
DP  - 1992 Apr
TI  - Effects of acute and chronic blockade of neutral endopeptidase with Sch 34826 on 
      NaCl-sensitive hypertension in spontaneously hypertensive rats.
PG  - 210-8
AB  - We have previously demonstrated that dietary NaCl supplementation is associated 
      with increased circulating atrial natriuretic peptide (ANP) levels in 
      Wistar-Kyoto (WKY) rats but not in spontaneously hypertensive rats (SHR), and 
      that replacement with exogenous ANP prevents NaCl-sensitive hypertension in 
      NaCl-sensitive SHR (SHR-S). The current study tested the hypothesis that chronic 
      administration of the neutral endopeptidase (NEP) inhibitor Sch 34826 prevents 
      NaCl sensitive hypertension in SHR-S by increasing endogenous ANP. Male SHR-S 
      received Sch 34826 (90 mg/kg/day) or vehicle by gavage for 4 weeks beginning 
      immediately before the initiation of 1% or 8% NaCl diets at age 7 weeks. Sch 
      34826 prevented the increase in arterial pressure in response to 8% NaCl in 
      SHR-S, but had no effect on blood pressure in 1% NaCl fed SHR-S; plasma ANP 
      levels were increased by 63 and 68% in the 1% and 8% NaCl groups, respectively, 
      in response to Sch 34826. To examine the mechanism(s) of the antihypertensive 
      effect of Sch 34826 in NaCl-supplemented SHR-S, a single dose (90 mg/kg) of Sch 
      34826 or vehicle was administered by gavage to SHR-S that had consumed 1% or 8% 
      NaCl diets for 3 weeks. Sch 34826 abolished the NaCl-induced increase in blood 
      pressure 3 h after treatment in 8% NaCl fed SHR-S, but had no effect in SHR-S fed 
      the 1% NaCl diet. This effect was associated with increased urine volume and 
      urinary sodium, ANP, and cyclic GMP in 8% NaCl fed SHR-S.(ABSTRACT TRUNCATED AT 
      250 WORDS)
FAU - Jin, H
AU  - Jin H
AD  - Department of Medicine, University of Alabama, Birmingham.
FAU - Mathews, C
AU  - Mathews C
FAU - Chen, Y F
AU  - Chen YF
FAU - Yang, R
AU  - Yang R
FAU - Wyss, J M
AU  - Wyss JM
FAU - Esunge, P
AU  - Esunge P
FAU - Oparil, S
AU  - Oparil S
LA  - eng
GR  - HL-07457/HL/NHLBI NIH HHS/United States
GR  - HL-22544/HL/NHLBI NIH HHS/United States
GR  - HL-37722/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Analgesics)
RN  - 0 (Dioxolanes)
RN  - 0 (Dipeptides)
RN  - 0 (Protease Inhibitors)
RN  - 105262-04-2 (Sch 34826)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - 9NEZ333N27 (Sodium)
RN  - H2D2X058MU (Cyclic GMP)
SB  - IM
MH  - Administration, Oral
MH  - Analgesics/*pharmacology
MH  - Animals
MH  - Atrial Natriuretic Factor/urine
MH  - Blood Pressure/drug effects/physiology
MH  - Cyclic GMP/urine
MH  - Dioxolanes/*pharmacology
MH  - Dipeptides/*pharmacology
MH  - Hypertension/chemically induced/*physiopathology/urine
MH  - Male
MH  - Protease Inhibitors/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR/*physiology
MH  - Rats, Inbred WKY
MH  - Sodium/urine
MH  - Sodium Chloride/administration & dosage/*adverse effects
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
AID - 10.1093/ajh/5.4.210 [doi]
PST - ppublish
SO  - Am J Hypertens. 1992 Apr;5(4 Pt 1):210-8. doi: 10.1093/ajh/5.4.210.