PMID- 1318123
OWN - NLM
STAT- MEDLINE
DCOM- 19920713
LR  - 20191028
IS  - 0941-0198 (Print)
IS  - 0941-0198 (Linking)
VI  - 70
IP  - 1
DP  - 1992 Jan
TI  - The diagnostic significance of antibody specificity indices in multiple sclerosis 
      and herpes virus induced diseases of the nervous system.
PG  - 28-37
AB  - The antibody specificity index (ASI) indicates the cerebrospinal fluid 
      (CSF)/serum difference of antibody amounts per weight unit IgG (normal less than 
      1.5). It has proven to be the most sensitive inflammation parameter in CSF 
      analysis so far, more sensitive than the Western blot, the "oligoclonal" 
      response, and the empirical differentiation of CSF immunoglobulins. By this 
      diagnostic criterion, several benign viral meningitis cases were found to be 
      caused by the varicella/zoster virus. The diagnostic relevance of local zoster 
      antibody synthesis was greatest in ganglionitis cases, e.g., in zoster oticus 
      sine herpete (facial paresis) and acute radicular syndromes of the elderly. The 
      diagnostic significance of the local immune response against measles, rubella, 
      and zoster antigens (MRZ response) was ascertained further. Together with 
      oligoclonal gamma-globulin fractionation, there is now only 1 out of 100 multiple 
      sclerosis (MS) patients left who has been found to have a normal CSF.
FAU - Felgenhauer, K
AU  - Felgenhauer K
AD  - Klinik und Poliklinik fur Neurologie, Georg-August-Universitat, Gottingen.
FAU - Reiber, H
AU  - Reiber H
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Investig
JT  - The Clinical investigator
JID - 9207154
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Viral/*cerebrospinal fluid
MH  - Antibody Specificity/*immunology
MH  - Female
MH  - Herpes Simplex/*diagnosis/immunology
MH  - Herpes Zoster/*diagnosis/immunology
MH  - Herpesvirus 3, Human/immunology
MH  - Humans
MH  - Immunoglobulin G/*cerebrospinal fluid
MH  - Male
MH  - Measles virus/immunology
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnosis/immunology
MH  - Nervous System Diseases/*diagnosis/immunology
MH  - Neurologic Examination
MH  - Simplexvirus/immunology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1007/BF00422934 [doi]
PST - ppublish
SO  - Clin Investig. 1992 Jan;70(1):28-37. doi: 10.1007/BF00422934.