PMID- 1318614
OWN - NLM
STAT- MEDLINE
DCOM- 19920716
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 189
IP  - 1
DP  - 1992 Jul
TI  - Maturation of mouse mammary tumor virus envelope protein is blocked by a specific 
      point mutation.
PG  - 393-6
AB  - Expression of a mouse mammary tumor virus (MMTV) envelope gene, ENV2, in COS-7 
      cells resulted in the synthesis of a precursor protein Pr74 that underwent 
      complete proteolytic processing to the mature envelope species gp52 and gp33. In 
      contrast, expression of a second MMTV envelope gene, ENV1, in COS-7 cells 
      resulted in the synthesis of a precursor protein Pr74 that failed to undergo 
      proteolytic processing to the mature products. Expression and sequencing of 
      various chimeric ENV1/ENV2 genes determined that a single glycine-to-glutamic 
      acid mutation at position 54 was responsible for the nonprocessable phenotype of 
      ENV1-encoded Pr74. The significance of this point mutation in relation to the 
      requirements for precursor protein folding and maturation are discussed.
FAU - Bedgood, R M
AU  - Bedgood RM
AD  - Department of Pathology, University of Southern California Health Sciences 
      Center, Los Angeles 90033.
FAU - Snider, L D
AU  - Snider LD
FAU - Stallcup, M R
AU  - Stallcup MR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Protein Precursors)
RN  - 0 (Viral Envelope Proteins)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Genes, env/*genetics
MH  - Mammary Tumor Virus, Mouse/*metabolism
MH  - Mutation/genetics
MH  - Protein Precursors/*metabolism
MH  - *Protein Processing, Post-Translational
MH  - Viral Envelope Proteins/*metabolism
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1016/0042-6822(92)90723-3 [doi]
PST - ppublish
SO  - Virology. 1992 Jul;189(1):393-6. doi: 10.1016/0042-6822(92)90723-3.