PMID- 1318910 OWN - NLM STAT- MEDLINE DCOM- 19920720 LR - 20190509 IS - 0022-1899 (Print) IS - 0022-1899 (Linking) VI - 166 IP - 1 DP - 1992 Jul TI - Replication of human herpesvirus 6 in epithelial cells in vitro. PG - 202-5 AB - Mink lung epithelial (NBL-7) cells were shown to be permissive for human herpesvirus 6 (HHV-6) by four independent methods of analysis: detection of infectious virus, viral antigens, viral DNA sequences, and herpesvirus particles. Infection was serially passaged, with minimal cytopathology, for several months demonstrating for the first time that a cell of epithelial origin can support HHV-6 replication. FAU - Simmons, A AU - Simmons A AD - Division of Medical Virology, Institute of Medical and Veterinary Science, Adelaide, Australia. FAU - Demmrich, Y AU - Demmrich Y FAU - La Vista, A AU - La Vista A FAU - Smith, K AU - Smith K LA - eng PT - Journal Article PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 RN - 0 (Antigens, Viral) RN - 0 (Culture Media) RN - 0 (DNA Probes) RN - 0 (DNA, Viral) SB - IM MH - Animals MH - Antigens, Viral/analysis MH - Cell Line MH - Culture Media MH - Cytopathogenic Effect, Viral MH - DNA Probes MH - DNA, Viral/analysis MH - Epithelium/microbiology MH - Fluorescent Antibody Technique MH - Herpesvirus 6, Human/genetics/immunology/isolation & purification/*physiology MH - Humans MH - Lung/*microbiology MH - Microscopy, Electron MH - Mink MH - Nucleic Acid Hybridization MH - Virion/isolation & purification MH - *Virus Replication EDAT- 1992/07/01 00:00 MHDA- 1992/07/01 00:01 CRDT- 1992/07/01 00:00 PHST- 1992/07/01 00:00 [pubmed] PHST- 1992/07/01 00:01 [medline] PHST- 1992/07/01 00:00 [entrez] AID - 10.1093/infdis/166.1.202 [doi] PST - ppublish SO - J Infect Dis. 1992 Jul;166(1):202-5. doi: 10.1093/infdis/166.1.202.