PMID- 1318935
OWN - NLM
STAT- MEDLINE
DCOM- 19920721
LR  - 20191028
IS  - 0883-0185 (Print)
IS  - 0883-0185 (Linking)
VI  - 8
IP  - 4
DP  - 1992
TI  - Endogenous ligands selecting T cells expressing particular V beta elements.
PG  - 289-309
AB  - It has recently become clear that the minor lymphocyte stimulatory antigens (Mls) 
      and other endogenous ligands which lead to the partial or total deletion of T 
      cells bearing particular V beta segments are encoded by mouse mammary tumor virus 
      (MMTV). We review here the genetic analyses of multiple V beta 11 and V beta 3 
      deletion ligands and demonstrate the involvement of MMTV in all examples. Several 
      features of Mls and the V beta 11/V beta 3 deleting ligands identify them as 
      members of the superantigen family. Bacterial superantigens are known to bind 
      both MHC class II and the TCR in regions distinct from conventional peptide 
      antigens. Within the MMTV genome, the 3' LTR has been identified as encoding 
      superantigen function. We present data demonstrating that in vitro translation 
      identifies the major product of the open reading frame (ORF) within the 3' LTR as 
      a type II integral membrane glycoprotein. It is proposed that the type II 
      membrane glycoprotein interacts with MHC and TCR in a manner analogous to the 
      bacterial superantigens and distinct from conventional peptide antigen. Several 
      unanswered questions regarding superantigen action remain; what determines total 
      or partial deletion? How is Mls transferred between cells? These questions are 
      addressed in the discussion.
FAU - Tomonari, K
AU  - Tomonari K
AD  - Transplantation Biology Section, MRC Clinical Research Centre, Harrow, Middlesex, 
      U.K.
FAU - Fairchild, S
AU  - Fairchild S
FAU - Rosenwasser, O A
AU  - Rosenwasser OA
FAU - Robinson, P J
AU  - Robinson PJ
FAU - Knight, A M
AU  - Knight AM
FAU - Dyson, P J
AU  - Dyson PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (Ligands)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Minor Lymphocyte Stimulatory Antigens)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
SB  - IM
MH  - Animals
MH  - Chromosome Deletion
MH  - Ligands
MH  - Major Histocompatibility Complex/genetics
MH  - Mammary Tumor Virus, Mouse/genetics
MH  - Membrane Glycoproteins/genetics
MH  - Minor Lymphocyte Stimulatory Antigens/genetics
MH  - Open Reading Frames
MH  - Receptors, Antigen, T-Cell, alpha-beta/*genetics
MH  - Signal Transduction
MH  - T-Lymphocytes/*immunology
RF  - 71
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.3109/08830189209053514 [doi]
PST - ppublish
SO  - Int Rev Immunol. 1992;8(4):289-309. doi: 10.3109/08830189209053514.