PMID- 1319510
OWN - NLM
STAT- MEDLINE
DCOM- 19920728
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 50
IP  - 2
DP  - 1992 Feb
TI  - [Platelet structure and function: immunocytochemical localizations of membrane 
      glycoprotein and alpha-granule protein].
PG  - 218-22
AB  - The platelet membrane glycoproteins (GPs) are receptors or binding sites for 
      adhesive proteins. GPIb and GPIIb/IIIa complex are major glycoproteins and have 
      important roles, functionally. GPIb plays an essential role in primary hemostasis 
      as receptor for the von Willebrand factor. The GPIIb/IIIa complex acts as the 
      binding site for adhesive proteins on activated platelets and, as such, is 
      essential for platelet aggregation. On the other hand, four adhesive proteins 
      (fibrinogen, fibronectin, thrombospondin and von Willebrand factor), which are 
      present not only in plasma but also in alpha-granules, mediate or modulate the 
      platelet adhesive response. The interaction between these adhesive proteins and 
      platelet membrane GPs are essential for platelet adhesion and aggregation. The 
      present report will focus on the localization of GPIb and GPIIb/IIIa on the 
      platelet surface and that of adhesive proteins in alpha-granules in both resting 
      and activated human platelets.
FAU - Suzuki, H
AU  - Suzuki H
AD  - Department of Cardiovascular Research, Tokyo Metropolitan Institute of Medical 
      Science.
FAU - Yamazaki, H
AU  - Yamazaki H
FAU - Tanoue, K
AU  - Tanoue K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Fibronectins)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Thrombospondins)
RN  - 0 (von Willebrand Factor)
RN  - 0 (von Willebrand factor receptor)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Blood Platelets/metabolism/*physiology
MH  - Cytoplasmic Granules/*metabolism
MH  - Fibrinogen/metabolism
MH  - Fibronectins/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Platelet Adhesiveness
MH  - Platelet Aggregation
MH  - Platelet Membrane Glycoproteins/*metabolism/physiology
MH  - Receptors, Cell Surface/metabolism
MH  - Thrombospondins
MH  - von Willebrand Factor/metabolism
EDAT- 1992/02/01 00:00
MHDA- 1992/02/01 00:01
CRDT- 1992/02/01 00:00
PHST- 1992/02/01 00:00 [pubmed]
PHST- 1992/02/01 00:01 [medline]
PHST- 1992/02/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1992 Feb;50(2):218-22.