PMID- 1320601
OWN - NLM
STAT- MEDLINE
DCOM- 19920813
LR  - 20190723
IS  - 0021-8820 (Print)
IS  - 0021-8820 (Linking)
VI  - 45
IP  - 5
DP  - 1992 May
TI  - WF11605, an antagonist of leukotriene B4 produced by a fungus. I. Producing 
      strain, fermentation, isolation and biological activity.
PG  - 698-703
AB  - WF11605, a new antagonist of leukotriene B4 (LTB4) was isolated as a product of 
      fungal strain F11605. The molecular formula of WF11605 was determined to be 
      C38H60O11. WF11605 inhibited LTB4-induced chemotaxis of rabbit polymorphonuclear 
      leukocytes (PMNLs) with an IC50 value of 1.7 x 10(-7) M and blocked 3H-LTB4 
      binding to PMNL membranes at 5.6 x 10(-6) M (IC50). WF11605 also inhibited 
      LTB4-induced degranulation of rabbit PMNLs at 3.0 x 10(-6) M (IC50). However, 
      WF11605 did not show any inhibitory effect on platelet activating factor (PAF)- 
      and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-induced degranulation at 
      concentrations up to 10(-4) M. These results suggest that WF11605 is a specific 
      antagonist of LTB4.
FAU - Tsujii, E
AU  - Tsujii E
AD  - Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, 
      Japan.
FAU - Tsurumi, Y
AU  - Tsurumi Y
FAU - Miyata, S
AU  - Miyata S
FAU - Fujie, K
AU  - Fujie K
FAU - Kawakami, A
AU  - Kawakami A
FAU - Okamoto, M
AU  - Okamoto M
FAU - Okuhara, M
AU  - Okuhara M
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Antibiot (Tokyo)
JT  - The Journal of antibiotics
JID - 0151115
RN  - 0 (Chrysenes)
RN  - 127475-47-2 (WF 11605)
RN  - 1HGW4DR56D (Leukotriene B4)
SB  - IM
MH  - Animals
MH  - Chrysenes/chemistry/*isolation & purification/pharmacology
MH  - Fermentation
MH  - Fungi/*chemistry
MH  - Leukotriene B4/*antagonists & inhibitors
MH  - Male
MH  - Mice
MH  - Rabbits
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.7164/antibiotics.45.698 [doi]
PST - ppublish
SO  - J Antibiot (Tokyo). 1992 May;45(5):698-703. doi: 10.7164/antibiotics.45.698.