PMID- 1321205
OWN - NLM
STAT- MEDLINE
DCOM- 19920818
LR  - 20081121
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 73 ( Pt 7)
DP  - 1992 Jul
TI  - The right end of the unique region of the genome of human herpesvirus 6 U1102 
      contains a candidate immediate early gene enhancer and a homologue of the human 
      cytomegalovirus US22 gene family.
PG  - 1649-60
AB  - The nucleotide sequence of a 12 kbp HindIII fragment (HindIII C) from the right 
      end of the unique component of the genome of human herpesvirus 6 (HHV-6) (strain 
      U1102) was determined. The sequence has a mean G + C content of 42% and contains 
      approximately 28 copies of a tandemly repeated 104 to 107 bp element, which, with 
      a single exception, contain a cleavage site for KpnI (the KpnI repeats). Each of 
      these elements contains potential binding sites for transcription factors 
      NF-kappa B and AP2. The KpnI repeats lie immediately upstream of a region 
      previously identified as a candidate immediate early (IE) gene locus and 
      therefore may constitute an IE gene enhancer element. One incomplete and six 
      complete open reading frames (ORFs) were identified in the unique sequence of the 
      HindIII C fragment. The predicted products of these ORFs do not include 
      homologues of proteins encoded by members of the alpha- or gamma-herpesvirus 
      sub-family. However, the HindIII C fragment does contain a homologue of the US22 
      gene family, previously found only in the beta-herpesvirus human cytomegalovirus 
      (HCMV). These findings provide evidence that the close phylogenetic relationship 
      between HHV-6 and HCMV is not confined to the beta-herpesvirus-specific 
      arrangement of conserved replicative and structural genes which has been 
      demonstrated previously.
FAU - Thomson, B J
AU  - Thomson BJ
AD  - Division of Virology, National Institute for Medical Research, London, U.K.
FAU - Honess, R W
AU  - Honess RW
LA  - eng
SI  - GENBANK/D11134
SI  - GENBANK/L07666
SI  - GENBANK/L07667
SI  - GENBANK/L07668
SI  - GENBANK/L07669
SI  - GENBANK/L07670
SI  - GENBANK/L07671
SI  - GENBANK/L07672
SI  - GENBANK/L07673
SI  - GENBANK/M77002
PT  - Journal Article
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (DNA, Viral)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cytomegalovirus/*genetics
MH  - DNA, Viral/chemistry
MH  - *Enhancer Elements, Genetic
MH  - *Genes, Viral
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - Repetitive Sequences, Nucleic Acid
MH  - *Sequence Homology, Nucleic Acid
MH  - Transcription, Genetic
MH  - Viral Proteins/chemistry
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1099/0022-1317-73-7-1649 [doi]
PST - ppublish
SO  - J Gen Virol. 1992 Jul;73 ( Pt 7):1649-60. doi: 10.1099/0022-1317-73-7-1649.