PMID- 1321206
OWN - NLM
STAT- MEDLINE
DCOM- 19920818
LR  - 20001218
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 73 ( Pt 7)
DP  - 1992 Jul
TI  - Identification of homologues to the human cytomegalovirus US22 gene family in 
      human herpesvirus 6.
PG  - 1661-71
AB  - The sequence of 10079 bp corresponding to the overlapping SalI H and SmaI G 
      restriction fragments of the genome of human herpesvirus 6 (HHV-6) strain U1102 
      was determined. The sequence contains six complete open reading frames (ORFs) and 
      two incomplete ORFs located at the 5' and 3' ends of the SalI H and SmaI G 
      fragments respectively. Seven of these ORFs have recognizable homologues only in 
      the beta-herpesvirus human cytomegalovirus (HCMV), no obvious counterparts being 
      detectable in the genomes of the human alpha-herpesviruses, varicella-zoster 
      virus and herpes simplex virus type 1 or the gamma-herpesvirus Epstein-Barr 
      virus. The DNA sequenced is located proximal to the left repeat of the HHV-6 
      genome outside the well recognized region encompassing conserved herpesvirus gene 
      blocks. A close colinear relationship is evident between the HHV-6 ORFs 
      identified in this study and their counterparts in HCMV, ORFs UL23, UL24 and UL27 
      to UL31. Four of the HHV-6 ORFs, SHL1, SHL2, SFL1 and SSL2, are related to 
      members of the HCMV US22 family of proteins, which are themselves tandemly 
      arranged and located predominantly within the unique short and the left end of 
      the unique long region of the prototype HCMV strain AD169 genome. Two adjacent 
      HHV-6 ORFs, SSL1 and SHL3, are related to HCMV UL27. The identification of this 
      gene set in addition to the HHV-6 ORFs with amino acid sequence similarity to the 
      HCMV US22 family indicates a particularly close relationship between these two 
      human herpesviruses, and suggests that the clustering of these related tandemly 
      arranged genes may be a general feature of beta-herpesvirus-type genomes.
FAU - Efstathiou, S
AU  - Efstathiou S
AD  - Department of Pathology, University of Cambridge, U.K.
FAU - Lawrence, G L
AU  - Lawrence GL
FAU - Brown, C M
AU  - Brown CM
FAU - Barrell, B G
AU  - Barrell BG
LA  - eng
SI  - GENBANK/D10082
SI  - GENBANK/L07666
SI  - GENBANK/L07667
SI  - GENBANK/L07668
SI  - GENBANK/L07669
SI  - GENBANK/L07670
SI  - GENBANK/L07671
SI  - GENBANK/L07672
SI  - GENBANK/L07673
SI  - GENBANK/M77002
PT  - Journal Article
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cytomegalovirus/*genetics
MH  - DNA, Viral/chemistry
MH  - *Genes, Viral
MH  - Herpesvirus 6, Human/*genetics
MH  - Molecular Sequence Data
MH  - Open Reading Frames
MH  - *Sequence Homology, Nucleic Acid
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1099/0022-1317-73-7-1661 [doi]
PST - ppublish
SO  - J Gen Virol. 1992 Jul;73 ( Pt 7):1661-71. doi: 10.1099/0022-1317-73-7-1661.