PMID- 1321207
OWN - NLM
STAT- MEDLINE
DCOM- 19920818
LR  - 20061115
IS  - 0022-1317 (Print)
IS  - 0022-1317 (Linking)
VI  - 73 ( Pt 7)
DP  - 1992 Jul
TI  - Experimental infection of cynomolgus and African green monkeys with human 
      herpesvirus 6.
PG  - 1673-7
AB  - Cynomolgus and African green monkeys were inoculated with human herpesvirus 6 
      (HHV-6). An antibody response was first observed 10 days and 5 days after 
      inoculation of cynomolgus monkeys and African green monkeys, respectively, and 
      was detectable for the duration of the experiment (33 days). HHV-6 DNA was first 
      detected by the polymerase chain reaction in mononuclear cells of one cynomolgus 
      monkey and one African green monkey 10 days after virus inoculation, and in a 
      total of three of four cynomolgus monkeys (75%) and four of five African green 
      monkeys (80%) later after inoculation. Furthermore, HHV-6 DNA was detected in the 
      lymph nodes and spleen of monkeys killed 33 days after virus inoculation. A rash 
      was observed on the trunk of one African green monkey 13 days after virus 
      inoculation, otherwise the infection was asymptomatic. When mononuclear cells 
      from both groups of monkeys were cultured in medium containing concanavalin A and 
      interleukin 2, and infected with HHV-6 in vitro, virus replication was observed. 
      The data suggest that HHV-6 infects these species of monkey and that this system 
      could be useful as an animal model of HHV-6 infection.
FAU - Yalcin, S
AU  - Yalcin S
AD  - Department of Virology, Osaka University, Japan.
FAU - Mukai, T
AU  - Mukai T
FAU - Kondo, K
AU  - Kondo K
FAU - Ami, Y
AU  - Ami Y
FAU - Okawa, T
AU  - Okawa T
FAU - Kojima, A
AU  - Kojima A
FAU - Kurata, T
AU  - Kurata T
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Gen Virol
JT  - The Journal of general virology
JID - 0077340
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/analysis
MH  - Cercopithecus
MH  - DNA, Viral/analysis
MH  - Disease Models, Animal
MH  - Herpesviridae Infections/immunology/*microbiology
MH  - *Herpesvirus 6, Human/immunology/isolation & purification
MH  - Macaca fascicularis
MH  - Virus Replication
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1099/0022-1317-73-7-1673 [doi]
PST - ppublish
SO  - J Gen Virol. 1992 Jul;73 ( Pt 7):1673-7. doi: 10.1099/0022-1317-73-7-1673.