PMID- 1321622
OWN - NLM
STAT- MEDLINE
DCOM- 19920820
LR  - 20181130
IS  - 0158-5231 (Print)
IS  - 0158-5231 (Linking)
VI  - 26
IP  - 6
DP  - 1992 May
TI  - New chemotactic peptide analogs with high biological activity for human 
      neutrophils.
PG  - 1125-35
AB  - As a part of a research programme aimed at studying structure activity 
      relationships in the field of chemotactic peptides, modified analogs of the 
      chemoattractant N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) were 
      examined for their capacity to activate several functions of human neutrophils. 
      4-Aminotetrahydrothiopyran-4carboxylic acid (Thp) and 2-aminoindane-2-carboxylic 
      acid (Ain) were chosen as achiral, conformationally restricted amino acids 
      suitable for mimicking the external Met and Phe residues of FMLP-OMe. The 
      replacement of both produces a high locomotion activity, greater than the parent 
      peptide; in contrast, the two Thp-containing analogs induce neither superoxide 
      production nor lysozyme release. From these results we can hypothesize two 
      different signal transduction systems: one which provides for movement, the other 
      for superoxide generation and granule enzyme release.
FAU - Spisani, S
AU  - Spisani S
AD  - Istituto di Chimica Biologica, Universita degli Studi di Ferrara, Italy.
FAU - Traniello, S
AU  - Traniello S
FAU - Giuliani, A L
AU  - Giuliani AL
FAU - Torrini, I
AU  - Torrini I
FAU - Pagani Zecchini, G
AU  - Pagani Zecchini G
FAU - Paglialunga Paradisi, M
AU  - Paglialunga Paradisi M
FAU - Gavuzzo, E
AU  - Gavuzzo E
FAU - Mazza, F
AU  - Mazza F
FAU - Pochetti, G
AU  - Pochetti G
FAU - Lucente, G
AU  - Lucente G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Biochem Int
JT  - Biochemistry international
JID - 8100311
RN  - 0 (Receptors, Formyl Peptide)
RN  - 0 (Receptors, Immunologic)
RN  - 11062-77-4 (Superoxides)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
RN  - EC 3.2.1.17 (Muramidase)
SB  - IM
MH  - Amino Acid Sequence
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Humans
MH  - In Vitro Techniques
MH  - Molecular Sequence Data
MH  - Molecular Structure
MH  - Muramidase/metabolism
MH  - N-Formylmethionine Leucyl-Phenylalanine/*analogs & 
      derivatives/chemistry/pharmacology
MH  - Neutrophils/*drug effects/physiology
MH  - Protein Conformation
MH  - Receptors, Formyl Peptide
MH  - Receptors, Immunologic/drug effects/physiology
MH  - Signal Transduction/drug effects
MH  - Superoxides/metabolism
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
PST - ppublish
SO  - Biochem Int. 1992 May;26(6):1125-35.