PMID- 1321644
OWN - NLM
STAT- MEDLINE
DCOM- 19920827
LR  - 20190819
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 9
IP  - 1
DP  - 1992 Jul
TI  - Neurotrophic factors promote the maturation of developing sensory neurons before 
      they become dependent on these factors for survival.
PG  - 139-50
AB  - We have studied the early development of chicken embryo sensory neurons in 
      culture before they become dependent on neurotrophic factors for survival. During 
      this period, they undergo a distinct change in morphology:initially they have 
      small, spindle-shaped, phase-dark cell bodies, which become spherical and phase 
      bright and extend long neurites. Although this maturational change occurs in 
      isolated cells grown in chemically defined medium, it is accelerated by 
      brain-derived neurotrophic factor (BDNF) or neurotrophin-3 and is retarded by 
      antisense oligonucleotides that inhibit expression of the common, low affinity 
      neurotrophic factor receptor (gp75NGFR) and by antisense BDNF oligonucleotides. 
      We conclude that neurotrophic factors play a role in the earliest stages of 
      sensory neuron development and suggest that they operate by an autocrine 
      mechanism at this time.
FAU - Wright, E M
AU  - Wright EM
AD  - Department of Anatomy, St. George's Hospital Medical School, Tooting, London, 
      England.
FAU - Vogel, K S
AU  - Vogel KS
FAU - Davies, A M
AU  - Davies AM
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Nerve Growth Factor)
SB  - IM
GS  - gp75<up>NGFR</up>
MH  - Animals
MH  - Autoradiography
MH  - Axons/physiology
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Movement/physiology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Chick Embryo
MH  - Ganglia, Spinal/chemistry/cytology/ultrastructure
MH  - Gene Expression/genetics
MH  - Immunohistochemistry
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/pharmacology
MH  - Nerve Tissue Proteins/genetics/*pharmacology
MH  - Neurons, Afferent/cytology/*drug effects/ultrastructure
MH  - Neurotrophin 3
MH  - Oligonucleotides, Antisense/pharmacology
MH  - RNA, Messenger/genetics
MH  - Receptors, Cell Surface/analysis/genetics/physiology
MH  - Receptors, Nerve Growth Factor
MH  - Signal Transduction/physiology
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 0896-6273(92)90229-7 [pii]
AID - 10.1016/0896-6273(92)90229-7 [doi]
PST - ppublish
SO  - Neuron. 1992 Jul;9(1):139-50. doi: 10.1016/0896-6273(92)90229-7.