PMID- 1323763
OWN - NLM
STAT- MEDLINE
DCOM- 19920917
LR  - 20131121
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 358
IP  - 6387
DP  - 1992 Aug 13
TI  - Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid.
PG  - 587-91
AB  - Retinoid response pathways are mediated by two classes of receptors, the retinoic 
      acid receptors (RARs) and the retinoid X receptors (RXRs). A central question is 
      whether distinct response pathways are regulated by these two classes of 
      receptors. The observation that the stereoisomer 9-cis-retinoic acid binds with 
      high affinity to RXRs suggested that this retinoid has a distinct role in 
      controlling RXR activity, but it was almost simultaneously discovered that RXRs 
      function as auxiliary receptors for RARs and related receptors, and are essential 
      for DNA binding and function of those receptors. Hence, although RARs seem to 
      operate effectively only as heterodimeric RAR/RXR complexes, RXRs themselves 
      apparently function predominantly, if not exclusively, as auxiliary receptors. 
      Here we report that 9-cis-retinoic acid induces RXR homodimer formation. Our 
      results demonstrate a new mechanism for retinoid action by which a ligand-induced 
      homodimer mediates a distinct retinoid response pathway.
FAU - Zhang, X K
AU  - Zhang XK
AD  - Cancer Center, La Jolla Cancer Research Foundation, California.
FAU - Lehmann, J
AU  - Lehmann J
FAU - Hoffmann, B
AU  - Hoffmann B
FAU - Dawson, M I
AU  - Dawson MI
FAU - Cameron, J
AU  - Cameron J
FAU - Graupner, G
AU  - Graupner G
FAU - Hermann, T
AU  - Hermann T
FAU - Tran, P
AU  - Tran P
FAU - Pfahl, M
AU  - Pfahl M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Apolipoprotein A-I)
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Apolipoprotein A-I/genetics/metabolism
MH  - Base Sequence
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cell Line
MH  - Chloramphenicol O-Acetyltransferase/genetics/metabolism
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*metabolism
MH  - Genes, Regulator
MH  - Macromolecular Substances
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/metabolism
MH  - Receptors, Cell Surface/drug effects/genetics/*metabolism
MH  - Receptors, Retinoic Acid
MH  - Recombinant Fusion Proteins/metabolism
MH  - Retinoid X Receptors
MH  - Stereoisomerism
MH  - *Transcription Factors
MH  - Transfection
MH  - Tretinoin/metabolism/*pharmacology
EDAT- 1992/08/13 00:00
MHDA- 1992/08/13 00:01
CRDT- 1992/08/13 00:00
PHST- 1992/08/13 00:00 [pubmed]
PHST- 1992/08/13 00:01 [medline]
PHST- 1992/08/13 00:00 [entrez]
AID - 10.1038/358587a0 [doi]
PST - ppublish
SO  - Nature. 1992 Aug 13;358(6387):587-91. doi: 10.1038/358587a0.