PMID- 1323983
OWN - NLM
STAT- MEDLINE
DCOM- 19920924
LR  - 20041117
IS  - 0199-9885 (Print)
IS  - 0199-9885 (Linking)
VI  - 12
DP  - 1992
TI  - Regulation of gene expression by vitamin A: the role of nuclear retinoic acid 
      receptors.
PG  - 443-71
AB  - Over the past five years, a wealth of information has accumulated concerning the 
      molecular mechanisms mediating RA effects on gene expression. The molecular 
      cloning of the 3 retinoic acid receptors (RARs), of their 16 or so different 
      isoforms, and of the 3 retinoid X receptors (RXRs) as well as the identification 
      of at least 2 different active isomers of RA (all trans- and 9-cis-RA) and of 
      several different CRABPs and CRBPs now provide the essential tools to explain the 
      pleiotropy that has become associated with RA effects. In the years to come, a 
      concentrated effort to delineate the complex interactions between the various 
      components of the retinoid signal transduction system should shed light on the 
      mechanisms underlying pattern formation during vertebrate development and point 
      to new ways in which retinoids can be exploited therapeutically.
FAU - Petkovich, M
AU  - Petkovich M
AD  - Cancer Research Laboratories, Queen's University, Kingston, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Nutr
JT  - Annual review of nutrition
JID - 8209988
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 11103-57-4 (Vitamin A)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Binding Sites
MH  - Carrier Proteins/chemistry/*physiology
MH  - Cell Nucleus/*metabolism
MH  - Gene Expression Regulation/*drug effects
MH  - Molecular Sequence Data
MH  - Molecular Structure
MH  - Receptors, Retinoic Acid
MH  - Vitamin A/*pharmacology
RF  - 160
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1146/annurev.nu.12.070192.002303 [doi]
PST - ppublish
SO  - Annu Rev Nutr. 1992;12:443-71. doi: 10.1146/annurev.nu.12.070192.002303.