PMID- 1325358
OWN - NLM
STAT- MEDLINE
DCOM- 19921008
LR  - 20190623
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 214
IP  - 2-3
DP  - 1992 Apr 22
TI  - Antinociception after intracerebroventricular administration of naltrindole in 
      the mouse.
PG  - 273-6
AB  - Intracerebroventricular (i.c.v.) injection of the delta-opioid receptor 
      antagonist naltrindole hydrochloride (2.2-22.2 nmol) in mice produced a 
      dose-dependent increase in tail flick and hot plate latencies with respective 
      ED50 and 95% confidence limits of 10.6 (8.3-13.9) and 16.4 (9.2-62.3) nmol. This 
      increase in response latencies was antagonized by 1 mg/kg s.c. naloxone or by 
      i.c.v. coadministration of 1.4 nmol ICI-174,864, a selective peptidergic 
      delta-receptor antagonist. Pretreatment 24 h earlier with the irreversible 
      mu-receptor antagonist beta-funaltrexamine (6 nmol i.c.v.) or 1 h earlier with 
      the selective kappa-receptor antagonist nor-binaltorphimine (100 nmol i.c.v.) did 
      not attenuate the antinociceptive effects of naltrindole. These data indicate 
      that high doses of naltrindole may have agonist activity at supraspinal 
      delta-opioid receptors in the mouse.
FAU - Stapelfeld, A
AU  - Stapelfeld A
AD  - Neurological Diseases Research, G.D. Searle & Co., Chicago, IL 60077.
FAU - Hammond, D L
AU  - Hammond DL
FAU - Rafferty, M F
AU  - Rafferty MF
LA  - eng
GR  - DA06736/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Indoles)
RN  - 0 (Morphinans)
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Receptors, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 5S6W795CQM (Naltrexone)
RN  - G167Z38QA4 (naltrindole)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Indoles/*administration & dosage
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Morphinans/*administration & dosage
MH  - *Naltrexone/*analogs & derivatives
MH  - Narcotic Antagonists/administration & dosage
MH  - Nociceptors/*drug effects/physiology
MH  - Receptors, Opioid/drug effects/physiology
MH  - Receptors, Opioid, delta
EDAT- 1992/04/22 00:00
MHDA- 1992/04/22 00:01
CRDT- 1992/04/22 00:00
PHST- 1992/04/22 00:00 [pubmed]
PHST- 1992/04/22 00:01 [medline]
PHST- 1992/04/22 00:00 [entrez]
AID - 0014-2999(92)90129-R [pii]
AID - 10.1016/0014-2999(92)90129-r [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1992 Apr 22;214(2-3):273-6. doi: 10.1016/0014-2999(92)90129-r.