PMID- 1326073
OWN - NLM
STAT- MEDLINE
DCOM- 19921013
LR  - 20190814
IS  - 0024-4201 (Print)
IS  - 0024-4201 (Linking)
VI  - 27
IP  - 3
DP  - 1992 Mar
TI  - Peroxide dependent and independent lipid peroxidation: site-specific mechanisms 
      of initiation by chelated iron and inhibition by alpha-tocopherol.
PG  - 227-33
AB  - Peroxidation of linoleic acid (LA) was catalyzed by Fenton reagent (H2O2 and 
      Fe2+) in positively charged tetradecyltrimethylammonium bromide (TTAB) micelles, 
      but not in negatively charged sodium dodecylsulfate (SDS) micelles. However, more 
      hydroxyl radicals formed via the Fenton reaction were trapped by 
      N-t-butyl-alpha-phenyl-nitrone (PBN) in SDS micelles than in TTAB micelles. 
      Generation of linoleic acid alkoxy (LO) radicals by Fe2+ via reductive cleavage 
      of linoleic acid hydroperoxide (LOOH) resulted in peroxidation of LA and 
      formation of PBN-LO. adducts in SDS micelles, but not in TTAB micelles. This LOOH 
      dependent lipid peroxidation could be catalyzed in TTAB micelles in the presence 
      of a negatively charged iron chelator, nitrilotriacetic acid (NTA). LO radicals 
      formed by the LOOH dependent Fenton reaction were also trapped by PBN at the 
      surface of TTAB micelles in the presence of NTA, but not in its absence. The 
      consumption of a spin probe, 16-(N-oxyl-4,4'-dimethyloxazolidin-2-yl)stearic acid 
      (16-NS) during the LOOH dependent Fenton reaction in the presence of NTA was 
      higher in TTAB micelles of LA than in those of lauric acid (LauA), although the 
      rates and amounts of LO radicals formed in the two types of fatty acid micelles 
      were similar. The rates of 5-NS consumption in LA and LauA micelles were almost 
      the same, and were lower than the rate of 16-NS in LA micelles. NTA-Fe2+ 
      initiated peroxidation of LA in TTAB micelles without a lag time in the presence 
      of LOOH, but after a lag period, peroxidation occurred without LOOH.(ABSTRACT 
      TRUNCATED AT 250 WORDS)
FAU - Fukuzawa, K
AU  - Fukuzawa K
AD  - Faculty of Pharmaceutical Sciences, Tokushima University, Japan.
FAU - Fujii, T
AU  - Fujii T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Lipids
JT  - Lipids
JID - 0060450
RN  - 0 (Free Radicals)
RN  - 0 (Indicators and Reagents)
RN  - 0 (Iron Chelating Agents)
RN  - 0 (Linoleic Acids)
RN  - 0 (Micelles)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 0 (Trimethyl Ammonium Compounds)
RN  - 1406-18-4 (Vitamin E)
RN  - 9KJL21T0QJ (Linoleic Acid)
RN  - E1UOL152H7 (Iron)
RN  - KA90006V9D (Nitrilotriacetic Acid)
RN  - Y3IR7RCT6J (tetradecyltrimethylammonium)
SB  - IM
MH  - Electron Spin Resonance Spectroscopy
MH  - Free Radicals
MH  - Indicators and Reagents
MH  - *Iron
MH  - *Iron Chelating Agents
MH  - Linoleic Acid
MH  - Linoleic Acids/*chemistry
MH  - *Lipid Peroxidation
MH  - Micelles
MH  - *Nitrilotriacetic Acid
MH  - Quaternary Ammonium Compounds
MH  - Trimethyl Ammonium Compounds
MH  - *Vitamin E
EDAT- 1992/03/01 00:00
MHDA- 1992/03/01 00:01
CRDT- 1992/03/01 00:00
PHST- 1992/03/01 00:00 [pubmed]
PHST- 1992/03/01 00:01 [medline]
PHST- 1992/03/01 00:00 [entrez]
AID - 10.1007/BF02536183 [doi]
PST - ppublish
SO  - Lipids. 1992 Mar;27(3):227-33. doi: 10.1007/BF02536183.