PMID- 1327324
OWN - NLM
STAT- MEDLINE
DCOM- 19921102
LR  - 20191028
IS  - 0941-0198 (Print)
IS  - 0941-0198 (Linking)
VI  - 70
IP  - 6
DP  - 1992 Jun
TI  - Human cytomegalovirus (HCMV)-specific immunoglobulin E as a serologic marker for 
      HCMV infection in immunocompromised patients.
PG  - 497-502
AB  - An antibody capture assay using an enzyme-linked human cytomegalovirus (HCMV) 
      antigen for the detection of specific immunoglobulin E (IgE) was established. 
      IgG, M, and E responses to HCMV were studied in 497 sera obtained from 44 renal 
      transplant recipients and 51 acquired immunodeficiency syndrome (AIDS) patients. 
      The results were compared with those obtained from 58 HCMV-seropositive healthy 
      individuals. HCMV-specific IgE was detected in 11 (91.7%) renal transplant 
      recipients with primary HCMV infection. In contrast, antibodies of the IgG and 
      IgM classes were detected in only 6 (50.0%) of these patients. Specific IgE was 
      detected in 10 (90.9%) out of 11 renal allograft recipients suffering from 
      secondary HCMV infection. Significant IgG titer rises and IgM were detected in 2 
      (18.2%) and 6 (54.6%) of these patients, respectively. IgG titer rises and IgM 
      and IgE antibodies were seen in 5 (12.2%), 1 (2.4%) and 18 (43.9%) AIDS patients 
      respectively. All healthy immunocompetent HCMV-seropositive individuals were 
      tested IgE negative. The results obtained in our study indicate that IgE against 
      HCMV is a more reliable serologic marker for primary and secondary HCMV infection 
      than IgM in immunocompromised individuals, especially in organ transplant 
      recipients, since it is not affected by the prophylactic application of HCMV 
      hyperimmune globulin preparations.
FAU - Weber, B
AU  - Weber B
AD  - Abteilung fur Medizinische Virologie, Zentrum der Hygiene, Universitatskliniken 
      Frankfurt/Main.
FAU - Braun, W
AU  - Braun W
FAU - Tyralla, B
AU  - Tyralla B
FAU - Hamann, A
AU  - Hamann A
FAU - Doerr, H W
AU  - Doerr HW
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Investig
JT  - The Clinical investigator
JID - 9207154
RN  - 0 (Antigens, Surface)
RN  - 0 (Antigens, Viral)
RN  - 0 (Biomarkers)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (immediate-early proteins, cytomegalovirus)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*immunology
MH  - Antigens, Surface/isolation & purification
MH  - Antigens, Viral/*isolation & purification
MH  - Biomarkers/chemistry
MH  - Cytomegalovirus Infections/*immunology
MH  - Humans
MH  - *Immediate-Early Proteins
MH  - Immunocompromised Host
MH  - Immunoglobulin G/isolation & purification
MH  - Immunoglobulin M/isolation & purification
MH  - Kidney Transplantation/*immunology
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
AID - 10.1007/BF00210231 [doi]
PST - ppublish
SO  - Clin Investig. 1992 Jun;70(6):497-502. doi: 10.1007/BF00210231.