PMID- 1328826
OWN - NLM
STAT- MEDLINE
DCOM- 19921119
LR  - 20190819
IS  - 0385-5600 (Print)
IS  - 0385-5600 (Linking)
VI  - 36
IP  - 4
DP  - 1992
TI  - Antiviral activity of a bile pigment, biliverdin, against human herpesvirus 6 
      (HHV-6) in vitro.
PG  - 381-90
AB  - Biliverdin (BV), a bile pigment, was examined for its antiviral activity against 
      human herpesvirus-6 (HHV-6) in vitro. BV (10 micrograms/ml) markedly inhibited 
      HHV-6 replication in MT-4 cells when the cells were treated during a virus 
      adsorption period. Its antiviral effect was weakened when cells were treated 
      after adsorption. Treatment of cells with BV (40 micrograms/ml) 3 hr after virus 
      infection had no inhibitory effect on virus replication. Virus replication was 
      also significantly inhibited by treatment of MT-4 cells with BV (10 
      micrograms/ml) before infection, while the virions were not inactivated by BV (20 
      micrograms/ml). Bilirubin and urobilin, metabolic derivatives of BV, showed 
      slight inhibitory effects on virus replication in the cells. On the other hand, 
      BV had no potent inhibitory activity in the replication of herpes simplex virus-1 
      or human cytomegalovirus. These observations suggest that BV could interact with 
      MT-4 cells to inhibit an early stage of HHV-6 infection in a virus-specific 
      manner.
FAU - Nakagami, T
AU  - Nakagami T
AD  - Department of Virology, Osaka University, Japan.
FAU - Taji, S
AU  - Taji S
FAU - Takahashi, M
AU  - Takahashi M
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Microbiol Immunol
JT  - Microbiology and immunology
JID - 7703966
RN  - 1856-98-0 (Urobilin)
RN  - O9MIA842K9 (Biliverdine)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Animals
MH  - Bilirubin/pharmacology/toxicity
MH  - Biliverdine/*pharmacology/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Evaluation Studies as Topic
MH  - Herpesviridae Infections/*drug therapy
MH  - Herpesvirus 6, Human/*drug effects
MH  - Humans
MH  - Urobilin/pharmacology/toxicity
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1111/j.1348-0421.1992.tb02037.x [doi]
PST - ppublish
SO  - Microbiol Immunol. 1992;36(4):381-90. doi: 10.1111/j.1348-0421.1992.tb02037.x.