PMID- 1329479
OWN - NLM
STAT- MEDLINE
DCOM- 19921029
LR  - 20190622
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 70
IP  - 10
DP  - 1992 Oct 8
TI  - Comparison of lisinopril versus digoxin for congestive heart failure during 
      maintenance diuretic therapy. The Lisinopril-Digoxin Study Group.
PG  - 84C-90C
AB  - Lisinopril 5-20 mg once daily was compared with digoxin 0.125-0.375 mg once daily 
      in a double-blind, randomized, parallel-group study involving 217 patients with 
      mild-to-moderate heart failure (New York Heart Association [NYHA] grades II-III) 
      who were maintained on optimized diuretic therapy. After 6 weeks of treatment, 
      digoxin and lisinopril had increased exercise duration by 18 seconds (p = 0.015) 
      and 32 seconds (p = 0.0007), respectively, versus the baseline run-in period. The 
      difference between treatments was not statistically significant (p = 0.1343). 
      After 12 weeks, digoxin and lisinopril had increased exercise duration by 29 
      seconds and 51 seconds, respectively. The effect of digoxin compared with the 
      baseline value was not significant but that for lisinopril was (p = 0.0027). The 
      difference between treatments approached statistical significance (p = 0.0813). 
      There was no difference between lisinopril and digoxin with regard to their 
      effects on the frequency of ventricular ectopic counts, couplets, or nonsustained 
      ventricular tachycardia. Blood pressures were not significantly different between 
      treatments, although both systolic and diastolic blood pressure were consistently 
      lower in the lisinopril group throughout randomized treatment. The proportions of 
      patients demonstrating an improvement in NYHA grading were similar for both 
      lisinopril and digoxin. Both treatments had similar effects on the symptoms of 
      heart failure. Both drugs appeared to be equally well tolerated with a similar 
      frequency of adverse events reported for both drugs (30% for lisinopril vs 29% 
      for digoxin). Withdrawals from treatment were of a similar frequency for both 
      treatments.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Herlitz, J
AU  - Herlitz J
AD  - Division of Cardiology, Sahlgrenska Hospital, Gothenburg, Sweden.
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Dipeptides)
RN  - 0 (Diuretics)
RN  - 0 (Placebos)
RN  - 73K4184T59 (Digoxin)
RN  - E7199S1YWR (Lisinopril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensin-Converting Enzyme Inhibitors/administration & dosage/adverse 
      effects/*therapeutic use
MH  - Arrhythmias, Cardiac/physiopathology/prevention & control
MH  - Blood Pressure/drug effects
MH  - Digoxin/administration & dosage/adverse effects/*therapeutic use
MH  - Dipeptides/administration & dosage/adverse effects/*therapeutic use
MH  - Diuretics/*therapeutic use
MH  - Double-Blind Method
MH  - Electrocardiography, Ambulatory/drug effects
MH  - Exercise Test
MH  - Female
MH  - Heart Failure/*drug therapy/physiopathology
MH  - Humans
MH  - Lisinopril
MH  - Male
MH  - Middle Aged
MH  - Physical Exertion/drug effects
MH  - Placebos
EDAT- 1992/10/08 00:00
MHDA- 1992/10/08 00:01
CRDT- 1992/10/08 00:00
PHST- 1992/10/08 00:00 [pubmed]
PHST- 1992/10/08 00:01 [medline]
PHST- 1992/10/08 00:00 [entrez]
AID - 0002-9149(92)91363-9 [pii]
AID - 10.1016/0002-9149(92)91363-9 [doi]
PST - ppublish
SO  - Am J Cardiol. 1992 Oct 8;70(10):84C-90C. doi: 10.1016/0002-9149(92)91363-9.