PMID- 1330006
OWN - NLM
STAT- MEDLINE
DCOM- 19921208
LR  - 20190815
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 32
IP  - 2
DP  - 1992 Jul 15
TI  - EEG sleep in Cushing's disease and Cushing's syndrome: comparison with patients 
      with major depressive disorder.
PG  - 146-55
AB  - Because patients with Cushing' syndrome (CS) and Major depressive disorder (MDD) 
      share features of hypercortisolism and the depressive syndrome, we compared 
      electro-encephalographic (EEG) sleep in patients with pituitary-ACTH-dependent 
      Cushing's syndrome (Cushing's disease, CD), patients with ACTH-independent 
      Cushing's syndrome (AICS), patients with major depressive disorder (MDD), and 
      normal subjects. There were substantial similarities in the abnormal 
      polysomnography profiles of patients with CD, AICS, and MDD. All three patient 
      groups demonstrated poorer sleep continuity, shortened rapid eye movement (REM) 
      latency, and increased first REM period density compared with normal subjects. In 
      addition, AICS patients and MDD patients had elevated REM activity and density. 
      These findings are discussed in terms of models of pathophysiology that relate 
      abnormalities in sleep, mood, and hypothalamic-pituitary-adrenal function.
FAU - Shipley, J E
AU  - Shipley JE
AD  - Sleep Program, University of Michigan School of Medicine, Ann Arbor.
FAU - Schteingart, D E
AU  - Schteingart DE
FAU - Tandon, R
AU  - Tandon R
FAU - Pande, A C
AU  - Pande AC
FAU - Grunhaus, L
AU  - Grunhaus L
FAU - Haskett, R F
AU  - Haskett RF
FAU - Starkman, M N
AU  - Starkman MN
LA  - eng
GR  - 07378/PHS HHS/United States
GR  - MO1RR00042/RR/NCRR NIH HHS/United States
GR  - R0-1-MH43372/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adenoma/physiopathology/psychology
MH  - Adrenocorticotropic Hormone/*blood
MH  - Adult
MH  - Bipolar Disorder/*physiopathology/psychology
MH  - Circadian Rhythm/physiology
MH  - Cushing Syndrome/*physiopathology/psychology
MH  - Depressive Disorder/*physiopathology/psychology
MH  - Dexamethasone
MH  - Electroencephalography/*instrumentation
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Hypothalamo-Hypophyseal System/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Neurocognitive Disorders/*physiopathology/psychology
MH  - Pituitary Neoplasms/physiopathology/psychology
MH  - Pituitary-Adrenal System/physiopathology
MH  - Polysomnography/instrumentation
MH  - Reaction Time/physiology
MH  - Signal Processing, Computer-Assisted/*instrumentation
MH  - Sleep Stages/*physiology
MH  - Sleep, REM/physiology
EDAT- 1992/07/15 00:00
MHDA- 1992/07/15 00:01
CRDT- 1992/07/15 00:00
PHST- 1992/07/15 00:00 [pubmed]
PHST- 1992/07/15 00:01 [medline]
PHST- 1992/07/15 00:00 [entrez]
AID - 0006-3223(92)90017-T [pii]
AID - 10.1016/0006-3223(92)90017-t [doi]
PST - ppublish
SO  - Biol Psychiatry. 1992 Jul 15;32(2):146-55. doi: 10.1016/0006-3223(92)90017-t.