PMID- 1330288
OWN - NLM
STAT- MEDLINE
DCOM- 19921222
LR  - 20190815
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 63
IP  - 1
DP  - 1992 Oct 1
TI  - Verification of isochromosome 12p and identification of other chromosome 12 
      aberrations in gonadal and extragonadal human germ cell tumors by bicolor double 
      fluorescence in situ hybridization.
PG  - 8-16
AB  - A diverse group of gonadal and extragonadal human germ cell tumors (GCT) and 
      GCT-derived cell lines was examined for the presence of an i(12p) marker 
      chromosome and/or other abnormalities involving chromosome 12, especially 12p, by 
      bicolor double fluorescence in situ hybridization (FISH). For this purpose three 
      probes, pBS-12, M28, and p alpha 12H8, were used, allowing specific 
      identification of the entire chromosome 12, its short arm, and its 
      pericentromeric region, respectively. The presence of one or more copies of a 
      genuine i(12p) chromosome could be demonstrated in three GCT of the testis, in 
      one ovarian GCT, in one dysgenetic GCT, and in one extragonadal intracranial GCT. 
      Moreover, additional aberrations involving chromosome 12 were shown to be present 
      not only in i(12p) minus but also in i(12p) positive GCT. These data suggest that 
      the occurrence of such aberrations may be a common, although less clearly 
      perceptible and frequent, phenomenon in human GCT.
FAU - Suijkerbuijk, R F
AU  - Suijkerbuijk RF
AD  - Department of Human Genetics, University Hospital, Nijmegen, The Netherlands.
FAU - Looijenga, L
AU  - Looijenga L
FAU - de Jong, B
AU  - de Jong B
FAU - Oosterhuis, J W
AU  - Oosterhuis JW
FAU - Cassiman, J J
AU  - Cassiman JJ
FAU - Geurts van Kessel, A
AU  - Geurts van Kessel A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Brain Neoplasms/*genetics
MH  - *Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 12
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasms, Germ Cell and Embryonal/*genetics
MH  - Ovarian Neoplasms/*genetics
MH  - Testicular Neoplasms/*genetics
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
AID - 0165-4608(92)90056-E [pii]
AID - 10.1016/0165-4608(92)90056-e [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1992 Oct 1;63(1):8-16. doi: 10.1016/0165-4608(92)90056-e.