PMID- 1331222
OWN - NLM
STAT- MEDLINE
DCOM- 19921217
LR  - 20190907
IS  - 0165-1838 (Print)
IS  - 0165-1838 (Linking)
VI  - 39
IP  - 2
DP  - 1992 Jun 15
TI  - Chronic central administration of enalaprilat lowers blood pressure in 
      stroke-prone spontaneously hypertensive rats.
PG  - 119-26
AB  - Earlier studies on the cardiovascular effects of intracerebroventricular (i.c.v.) 
      administration of angiotensin converting enzyme (ACE) inhibitors implicate 
      angiotensin II (AII) present in the central nervous system in the pathogenesis of 
      hypertension. We have now examined whether central AII contributes to the 
      maintenance of established hypertension in adult stroke-prone spontaneously 
      hypertensive rats (SHRSP). The ACE inhibitor, enalaprilat, was infused i.c.v. for 
      two weeks at a rate of 5 micrograms/h via osmotic minipumps. Control rats were 
      either untreated or infused with saline. Mean arterial pressure (MAP), measured 
      via an indwelling catheter, fell within 24 h in the enalaprilat-treated rats and 
      remained at least 30 mmHg lower than in controls. This difference persisted after 
      intravenous (i.v.) administration of a vasopressin (AVP) antagonist but was 
      eliminated by subsequent ganglion blockade with i.v. pentolinium. Without prior 
      administration of the AVP antagonist, however, the reductions of MAP after 
      pentolinium were smaller. The reduction was still attenuated in treated rats 
      compared with controls but there was a significant difference in the residual 
      MAP. Circulating catecholamine levels were reduced by central ACE inhibition. 
      However, pressor responsiveness to i.v. phenylephrine was unaffected. The results 
      suggest that, in SHRSP, central ACE inhibition lowers blood pressure by reducing 
      sympathetic outflow, implying that central AII has a tonic sympathoexcitatory 
      effect in this strain.
FAU - Jablonskis, L T
AU  - Jablonskis LT
AD  - Division of Human Nutrition, Commonwealth Scientific and Industrial Research 
      Organisation, Adelaide, Australia.
FAU - Rogers, P F
AU  - Rogers PF
FAU - Lungershausen, Y K
AU  - Lungershausen YK
FAU - Howe, P R
AU  - Howe PR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Auton Nerv Syst
JT  - Journal of the autonomic nervous system
JID - 8003419
RN  - 953357GACY (Pentolinium Tartrate)
RN  - GV0O7ES0R3 (Enalaprilat)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Cerebrovascular Disorders/*prevention & control
MH  - Disease Models, Animal
MH  - Enalaprilat/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Epinephrine/blood
MH  - Hypertension/drug therapy
MH  - Injections, Intraventricular
MH  - Male
MH  - Norepinephrine/blood
MH  - Pentolinium Tartrate/pharmacology
MH  - Rats
MH  - Rats, Mutant Strains
EDAT- 1992/06/15 00:00
MHDA- 1992/06/15 00:01
CRDT- 1992/06/15 00:00
PHST- 1992/06/15 00:00 [pubmed]
PHST- 1992/06/15 00:01 [medline]
PHST- 1992/06/15 00:00 [entrez]
AID - 0165-1838(92)90052-I [pii]
AID - 10.1016/0165-1838(92)90052-i [doi]
PST - ppublish
SO  - J Auton Nerv Syst. 1992 Jun 15;39(2):119-26. doi: 10.1016/0165-1838(92)90052-i.