PMID- 1331537
OWN - NLM
STAT- MEDLINE
DCOM- 19921215
LR  - 20200724
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 66
IP  - 12
DP  - 1992 Dec
TI  - A mouse mammary tumor virus mammary gland enhancer confers tissue-specific but 
      not lactation-dependent expression in transgenic mice.
PG  - 7529-32
AB  - The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) is known to 
      contain a number of transcriptional regulatory elements, including glucocorticoid 
      response elements. In this study, we showed that a mammary gland/salivary gland 
      enhancer found in the LTR of this virus directs expression of a heterologous 
      promoter to both virgin and lactating mammary glands in transgenic mice. Using 
      transgenic mice containing hybrid gene constructs with various deletions of the 
      LTR sequences linked to marker genes, we also showed that the dramatic increase 
      in MMTV expression that occurs during lactation is due to the glucocorticoid 
      response elements. Thus, the MMTV LTR encodes two distinct elements, both of 
      which are required for a high level of expression in lactating mammary glands.
FAU - Mok, E
AU  - Mok E
AD  - Department of Biochemistry, University of Illinois, Chicago 60612.
FAU - Golovkina, T V
AU  - Golovkina TV
FAU - Ross, S R
AU  - Ross SR
LA  - eng
GR  - CA45954/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Chloramphenicol O-Acetyltransferase/genetics/metabolism
MH  - *Enhancer Elements, Genetic
MH  - Female
MH  - *Gene Expression Regulation, Viral
MH  - Lactation/*physiology
MH  - Mammary Glands, Animal/microbiology
MH  - Mammary Tumor Virus, Mouse/*genetics
MH  - Mice
MH  - Mice, Transgenic
MH  - Organ Specificity
MH  - *Repetitive Sequences, Nucleic Acid
PMC - PMC240463
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
PMCR- 1992/12/01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
PHST- 1992/12/01 00:00 [pmc-release]
AID - 10.1128/JVI.66.12.7529-7532.1992 [doi]
PST - ppublish
SO  - J Virol. 1992 Dec;66(12):7529-32. doi: 10.1128/JVI.66.12.7529-7532.1992.