PMID- 1331831
OWN - NLM
STAT- MEDLINE
DCOM- 19921216
LR  - 20180215
IS  - 1660-8151 (Print)
IS  - 1660-8151 (Linking)
VI  - 62
IP  - 1
DP  - 1992
TI  - Low molecular weight heparin (CY-216) versus unfractionated heparin in chronic 
      hemodialysis.
PG  - 13-7
AB  - In 14 patients undergoing chronic hemodialysis, we investigated the safety and 
      efficacy of the low molecular fragment (CY-216) in comparison to unfractionated 
      heparin (UFH) in the prevention of clotting in the extracorporeal circuit (ECC). 
      In this study, 168 hemodialysis sessions were undertaken with UFH in 2 bolus 
      doses (5,437 +/- 1,477 SD IU) and 231 with CY-216 in a single bolus dose [initial 
      dose 150 anti-Xa U Institut Choay (IC)/kg]. There were no clots in the bubble 
      trap in any UFH sessions, and 14.8% had coagulated fibers in the dialyzer. 
      Clotting in the bubble trap was observed in 2 CY-216 sessions (0.8%) and 
      coagulated fibers in 22.6% of the sessions. At the end of the study, the mean 
      dose of CY-216 was 250 anti-Xa UIC/kg but a dose of 350 anti-Xa UIC/kg was needed 
      in the 2 patients treated by recombinant human erythropoietin. Anti-Xa levels at 
      the end of the runs were higher (0.47 +/- 0.1 U/ml) in the CY-216 group than in 
      the UFH group (0.28 +/- 0.1 U/ml). There was a correlation between anti-Xa levels 
      and efficacy in the CY-216 group. An anti-Xa activity above 0.4 U/ml was needed 
      in order to minimize thrombus formation. Antithrombin III-protease complexes 
      (ATM) and D dimer fibrin derivatives (D dimer) were used as thrombotic markers 
      but they were of little value for the detection of fibrin formation in the ECC. 
      Our findings suggest that CY-216 administered as a single bolus dose seems to be 
      of similar effectiveness to UFH.
FAU - Grau, E
AU  - Grau E
AD  - Department of Hematology, Hospital Lluis Alcanyis, Xativa, Spain.
FAU - Siguenza, F
AU  - Siguenza F
FAU - Maduell, F
AU  - Maduell F
FAU - Linares, M
AU  - Linares M
FAU - Olaso, M A
AU  - Olaso MA
FAU - Martinez, R
AU  - Martinez R
FAU - Caridad, A
AU  - Caridad A
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Nephron
JT  - Nephron
JID - 0331777
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9000-94-6 (Antithrombin III)
RN  - 9001-31-4 (Fibrin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Antithrombin III
MH  - Blood Coagulation/drug effects
MH  - Blood Coagulation Disorders/diagnosis
MH  - *Extracorporeal Circulation
MH  - Female
MH  - Fibrin
MH  - Heparin/*standards/therapeutic use
MH  - Heparin, Low-Molecular-Weight/*standards/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Renal Dialysis
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000186987 [doi]
PST - ppublish
SO  - Nephron. 1992;62(1):13-7. doi: 10.1159/000186987.