PMID- 1333639
OWN - NLM
STAT- MEDLINE
DCOM- 19930106
LR  - 20190814
IS  - 0036-5521 (Print)
IS  - 0036-5521 (Linking)
VI  - 27
IP  - 11
DP  - 1992 Nov
TI  - Haemorrhagic effect of enoxaparin, a low molecular weight heparin. Comparison 
      with unfractionated heparin in humans.
PG  - 924-8
AB  - The haemorrhagic effects of unfractionated heparin (UFH) and the low molecular 
      weight heparin (LMWH) enoxaparin were investigated and compared in the gastric 
      mucosa (haemorrhage induced by biopsy) and skin (haemorrhage induced by Simplate) 
      of 12 healthy volunteers. Administration of UFH and LMWH (given in a dose of 75 
      anti-Xa U/kg intravenously) increased median gastric bleeding time (3.5 min) and 
      geometric mean blood loss (11.5 microliters) to 19 min (p = 0.00003) and 54.1 
      microliters (p = 0.0021) after UFH and to 13 min (p = 0.008) and 29.0 microliters 
      (p = 0.275) after LMWH. Median skin bleeding time (4.25 min) increased to 6.0 min 
      after UFH (p = 0.003) and to 6.75 min after LMWH (p = 0.0008). Mean heparin 
      activity in plasma was 20% higher after LMWH than after UFH. The calculated 
      gastric bleeding time to heparin activity ratio was significantly lower for LMWH 
      than for UFH (p < 0.05).
FAU - Bang, C J
AU  - Bang CJ
AD  - Division of Gastroenterology, Medical Dept., Haukeland University Hospital, 
      Bergen, Norway.
FAU - Riedel, B
AU  - Riedel B
FAU - Talstad, I
AU  - Talstad I
FAU - Berstad, A
AU  - Berstad A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Scand J Gastroenterol
JT  - Scandinavian journal of gastroenterology
JID - 0060105
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - *Bleeding Time
MH  - Female
MH  - Gastrointestinal Hemorrhage/*chemically induced
MH  - Gastroscopy
MH  - Heparin/administration & dosage/*adverse effects
MH  - Heparin, Low-Molecular-Weight/administration & dosage/*adverse effects
MH  - Humans
MH  - Intestinal Mucosa/drug effects/pathology
MH  - Male
MH  - Middle Aged
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
AID - 10.3109/00365529209000164 [doi]
PST - ppublish
SO  - Scand J Gastroenterol. 1992 Nov;27(11):924-8. doi: 10.3109/00365529209000164.