PMID- 1333845
OWN - NLM
STAT- MEDLINE
DCOM- 19930111
LR  - 20190911
IS  - 1058-2916 (Print)
IS  - 1058-2916 (Linking)
VI  - 38
IP  - 3
DP  - 1992 Jul-Sep
TI  - Long-term use of low molecular weight heparin ameliorates hyperlipidemia in 
      patients on hemodialysis.
PG  - M326-30
AB  - Hyperlipidemia is one of the major risk factors for cardiovascular death in 
      long-term hemodialysis (HD) patients. To clarify whether unfractionated heparin 
      (UFH) contributes to the pathogenesis of hyperlipidemia, nine Type IIb, seven 
      Type IV, and 10 normolipidemic patients, who had been dialyzed with 80.7 IU/Kg 
      heparin, were dialyzed with 40 anti-Xa U/kg of low molecular weight heparin 
      (LMWH) (Logiparin, Novo-Nordisk, Gentfe, Denmark) for 6 months. Seven 
      normolipidemic patients were also dialyzed with heparin as controls. Decreases in 
      triglyceride (TG) during HD with LMWH were significantly less than those with 
      heparin. However, lipoprotein lipase activities (LPL) during HD with LMWH and 
      heparin, and those before and after 6 months on LMWH, were no different. During 
      the 6 months on LMWH, serum total cholesterol, TG, and alpha lipoprotein 
      significantly decreased in Type IIb patients but did not change in Type IV. In 
      contrast, beta lipoprotein slightly increased in Types IIb, IV, and 
      normolipidemic patients who were dialyzed with LMWH but was unchanged in the 
      controls. These observations suggest that UFH aggravates hyperlipidemia in 
      patients, but these effects cannot be attributed to depletion of endothelial LPL 
      liberated by UFH.
FAU - Akiba, T
AU  - Akiba T
AD  - Tokyo Medical University, Department of Internal Medicine, Japan.
FAU - Tachibana, K
AU  - Tachibana K
FAU - Ozawa, K
AU  - Ozawa K
FAU - Chida, Y
AU  - Chida Y
FAU - Ogasawara, H
AU  - Ogasawara H
FAU - Yoshiyama, N
AU  - Yoshiyama N
FAU - Hoshino, M
AU  - Hoshino M
FAU - Inada, T
AU  - Inada T
FAU - Marumo, F
AU  - Marumo F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
RN  - 0 (Heparin, Low-Molecular-Weight)
RN  - 0 (Lipids)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.1.1.34 (Lipoprotein Lipase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Heparin/adverse effects
MH  - Heparin, Low-Molecular-Weight/*therapeutic use
MH  - Humans
MH  - Hyperlipidemias/blood/etiology/*prevention & control
MH  - Lipids/blood
MH  - Lipoprotein Lipase/blood
MH  - Male
MH  - Middle Aged
MH  - Renal Dialysis/*adverse effects
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
AID - 10.1097/00002480-199207000-00047 [doi]
PST - ppublish
SO  - ASAIO J. 1992 Jul-Sep;38(3):M326-30. doi: 10.1097/00002480-199207000-00047.