PMID- 1333971
OWN - NLM
STAT- MEDLINE
DCOM- 19930113
LR  - 20190623
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 221
IP  - 1
DP  - 1992 Oct 6
TI  - Effects of naloxone infusion upon spontaneous and amphetamine-induced activity.
PG  - 161-5
AB  - Naloxone-filled (1.0 mg/kg per h) or sham pumps were implanted subcutaneously 
      (s.c.) in rats on day 0 and removed on day 7. Spontaneous locomotor activity was 
      lower in naloxone-infused rats on day 3 only. Cumulative dose-response curves to 
      D-amphetamine were constructed in separate groups on day 6 or day 8 (0.0-6.4 
      mg/kg s.c.). On day 6, naloxone infusion attenuated the gross movement response 
      to D-amphetamine, but not the fine movement response. There were no differences 
      in the response of naloxone- or sham-infused rats to D-amphetamine on day 8. 
      Therefore, withdrawal from continuous naloxone infusion had no influence upon 
      spontaneous or D-amphetamine-stimulated activity.
FAU - Jones, D N
AU  - Jones DN
AD  - Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 
      30322.
FAU - Holtzman, S G
AU  - Holtzman SG
LA  - eng
GR  - DA00541/DA/NIDA NIH HHS/United States
GR  - K05 DA00008/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Receptors, Opioid, mu)
RN  - 36B82AMQ7N (Naloxone)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Dextroamphetamine/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Drug Interactions
MH  - Male
MH  - Motor Activity/*drug effects
MH  - Naloxone/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Opioid, mu/drug effects
EDAT- 1992/10/06 00:00
MHDA- 1992/10/06 00:01
CRDT- 1992/10/06 00:00
PHST- 1992/10/06 00:00 [pubmed]
PHST- 1992/10/06 00:01 [medline]
PHST- 1992/10/06 00:00 [entrez]
AID - 0014-2999(92)90787-5 [pii]
AID - 10.1016/0014-2999(92)90787-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1992 Oct 6;221(1):161-5. doi: 10.1016/0014-2999(92)90787-5.