PMID- 1334295
OWN - NLM
STAT- MEDLINE
DCOM- 19930114
LR  - 20061115
IS  - 0340-2592 (Print)
IS  - 0340-2592 (Linking)
VI  - 31
IP  - 6
DP  - 1992 Nov
TI  - [Wilm's tumor 1992. State of research and results of current therapeutic 
      concepts].
PG  - 360-7
AB  - Wilms' tumor is the most frequent and most important pediatric tumor in urologic 
      oncology. In recent years the prognosis of Wilms' tumor has improved markedly and 
      a cure rate of more than 80% can be achieved by means of standardized therapy 
      protocols such as those established by the National Wilms' Tumor Study (NWTS), 
      the Societe Internationale d'Oncologie Pediatrique (SIOP), and the German Society 
      of Pediatric Oncology (GPO). However, since the number of long-term survivors is 
      now expected to increase, serious long-term complications must be taken into 
      account, especially after radiation therapy, and treatment modalities must be 
      modified with due consideration for toxicity and late effects of treatment. 
      Refinement of treatment protocols is therefore the main aim to two studies, 
      SIOP-9/GPO and NWTS-4. In Germany, children with Wilms' tumor are now treated 
      according to the SIOP-9/GPO protocol including preoperative chemotherapy. 
      Preoperative chemotherapy can reduce tumor volume markedly, leading to a 
      significantly higher proportion of children with stage I/II tumors at the time of 
      surgery. Thus, postoperative chemotherapy can be reduced and radiation therapy 
      avoided in children in whom stage III tumors would other wise have to be 
      expected. Radiation therapy of pulmonary metastases can be restricted to children 
      who have not responded to prior chemotherapy, whereas in others it seems 
      tumor-free survival can be achieved by extirpation of the remaining pulmonary 
      metastases alone following chemotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Zoller, G
AU  - Zoller G
AD  - Urologische Universitatsklinik, Georg-August-Universitat Gottingen.
FAU - Lakomek, M
AU  - Lakomek M
FAU - Ringert, R H
AU  - Ringert RH
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Wilms-Tumor 1992. Stand der Forschung und Ergebnisse gegenwartiger 
      Therapiekonzepte.
PL  - Germany
TA  - Urologe A
JT  - Der Urologe. Ausg. A
JID - 1304110
SB  - IM
MH  - Chemotherapy, Adjuvant
MH  - Child
MH  - Combined Modality Therapy
MH  - Humans
MH  - Kidney Neoplasms/drug therapy/mortality/radiotherapy/*surgery
MH  - Nephrectomy
MH  - Survival Rate
MH  - Wilms Tumor/drug therapy/mortality/radiotherapy/*surgery
RF  - 20
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PST - ppublish
SO  - Urologe A. 1992 Nov;31(6):360-7.