PMID- 1334662
OWN - NLM
STAT- MEDLINE
DCOM- 19930128
LR  - 20071114
IS  - 0922-9833 (Print)
IS  - 0922-9833 (Linking)
VI  - 7
DP  - 1992
TI  - The dentate gyrus: a model system for studies of neurotrophin regulation.
PG  - 171-85
AB  - Studies of the hippocampal formation have demonstrated that seizure activity 
      stimulates a complex pattern of changes in gene expression in differentiated 
      adult neurons including alterations in levels of mRNAs encoding putative 
      neurotransmitter/neuromodulator substances and neurotransmitter receptors. Thus, 
      activity-dependent alterations in gene expression can be expected to effect 
      transient changes in synaptic physiology by modification of both presynaptic and 
      postsynaptic constituents. In work to be reviewed here, seizure paradigms have 
      been utilized to study the influence of activity on the expression of the nerve 
      growth factor (NGF) family of neurotrophins by the dentate gyrus granule cells. 
      We have found that seizures increase the expression of mRNAs for NGF and 
      brain-derived neurotrophic factor (BDNF) but cause a delayed decrease in levels 
      of mRNA for neurotrophin-3 (NT-3) in the granule cells of the dentate gyrus. 
      Differences in the time courses of neurotrophin induction by seizure suggest that 
      multiple regulatory mechanisms are involved. These findings indicate that 
      physiological activity differentially regulates the expression of the three 
      neurotrophins within individual adult forebrain neurons. Moreover, the induction 
      of neurotrophin expression by seizure suggests a mechanism by which epileptiform 
      activity might leave an enduring trace in the functional and structural 
      properties of forebrain circuits which might influence the susceptibility for 
      further seizure activity.
FAU - Gall, C
AU  - Gall C
AD  - Department of Anatomy and Neurobiology, University of California, Irvine 92717.
FAU - Lauterborn, J
AU  - Lauterborn J
LA  - eng
GR  - AG00538/AG/NIA NIH HHS/United States
GR  - MH10008/MH/NIMH NIH HHS/United States
GR  - NS26748/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - Epilepsy Res Suppl
JT  - Epilepsy research. Supplement
JID - 8913231
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Electric Stimulation
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/*pathology/physiopathology
MH  - Nerve Growth Factors/*genetics/physiology
MH  - Nerve Tissue Proteins/*genetics
MH  - Neuronal Plasticity/genetics/physiology
MH  - Neurotrophin 3
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Seizures/*genetics/pathology/physiopathology
MH  - Synaptic Transmission/*genetics/physiology
RF  - 81
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Epilepsy Res Suppl. 1992;7:171-85.