PMID- 1335166
OWN - NLM
STAT- MEDLINE
DCOM- 19930125
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 258
IP  - 5090
DP  - 1992 Dec 18
TI  - Retinoids selective for retinoid X receptor response pathways.
PG  - 1944-6
AB  - Retinoids have a broad spectrum of biological activities and are useful 
      therapeutic agents. Their physiological activities are mediated by two types of 
      receptors, the retinoic acid receptors (RARs) and the retinoid X receptors 
      (RXRs). RARs, as well as several related receptors, require heterodimerization 
      with RXRs for effective DNA binding and function. However, in the presence of 
      9-cis-retinoic acid, a ligand for both RARs and RXRs, RXRs can also form 
      homodimers. A series of retinoids is reported that selectively activates RXR 
      homodimers but does not affect RAR-RXR heterodimers and thus demonstrates that 
      both retinoid response pathways can be independently activated.
FAU - Lehmann, J M
AU  - Lehmann JM
AD  - Cancer Center, La Jolla Cancer Research Foundation, La Jolla, CA 92037.
FAU - Jong, L
AU  - Jong L
FAU - Fanjul, A
AU  - Fanjul A
FAU - Cameron, J F
AU  - Cameron JF
FAU - Lu, X P
AU  - Lu XP
FAU - Haefner, P
AU  - Haefner P
FAU - Dawson, M I
AU  - Dawson MI
FAU - Pfahl, M
AU  - Pfahl M
LA  - eng
GR  - CA50676/CA/NCI NIH HHS/United States
GR  - P01 CA51993/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Macromolecular Substances)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Transcription Factors)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.3.1.28 (Chloramphenicol O-Acetyltransferase)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Chloramphenicol O-Acetyltransferase/genetics/metabolism
MH  - Kinetics
MH  - Macromolecular Substances
MH  - Molecular Structure
MH  - Receptors, Cell Surface/drug effects/genetics/*metabolism
MH  - *Receptors, Retinoic Acid
MH  - Recombinant Fusion Proteins/metabolism
MH  - Retinoid X Receptors
MH  - Retinoids/chemistry/*metabolism/pharmacology
MH  - Structure-Activity Relationship
MH  - *Transcription Factors
MH  - Transcription, Genetic
MH  - Transfection
MH  - Tretinoin/metabolism/pharmacology
EDAT- 1992/12/18 00:00
MHDA- 1992/12/18 00:01
CRDT- 1992/12/18 00:00
PHST- 1992/12/18 00:00 [pubmed]
PHST- 1992/12/18 00:01 [medline]
PHST- 1992/12/18 00:00 [entrez]
AID - 10.1126/science.1335166 [doi]
PST - ppublish
SO  - Science. 1992 Dec 18;258(5090):1944-6. doi: 10.1126/science.1335166.