PMID- 1335240
OWN - NLM
STAT- MEDLINE
DCOM- 19930128
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 189
IP  - 2
DP  - 1992 Dec 15
TI  - Differentiation-inducing activity of retinoic acid isomers and their oxidized 
      analogs on human promyelocytic leukemia HL-60 cells.
PG  - 1136-42
AB  - Retinoidal activity of retinoic acid isomers [all-trans-retinoic acid (ATRA), 
      9-cis-retinoic acid (9CRA) and 13-cis-retinoic acid (13CRA)] and their oxidized 
      derivatives [19-hydroxy and 19-oxo derivatives of ATRA (19-hydroxy-ATRA and 
      19-oxo-ATRA), 19-oxo derivative of 9CRA (19-oxo-9CRA), and 19-hydroxy derivative 
      of 13CRA (19-hydroxy-13CRA)] was evaluated by means of a human promyelocytic 
      leukemia HL-60 cell differentiation induction assay. All the compounds examined 
      showed this activity with ED50 values of 2-30 nM, which are in accordance with 
      their binding activity to nuclear retinoic acid receptors (RARs).
FAU - Matsushima, Y
AU  - Matsushima Y
AD  - Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
FAU - Kawachi, E
AU  - Kawachi E
FAU - Tanaka, H
AU  - Tanaka H
FAU - Kagechika, H
AU  - Kagechika H
FAU - Hashimoto, Y
AU  - Hashimoto Y
FAU - Shudo, K
AU  - Shudo K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Carrier Proteins)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Binding, Competitive
MH  - Carrier Proteins/metabolism
MH  - Cell Differentiation/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Isomerism
MH  - Leukemia, Promyelocytic, Acute
MH  - Molecular Structure
MH  - Oxidation-Reduction
MH  - Receptors, Retinoic Acid
MH  - Structure-Activity Relationship
MH  - Tretinoin/*analogs & derivatives/metabolism/*pharmacology
MH  - Tumor Cells, Cultured
EDAT- 1992/12/15 00:00
MHDA- 1992/12/15 00:01
CRDT- 1992/12/15 00:00
PHST- 1992/12/15 00:00 [pubmed]
PHST- 1992/12/15 00:01 [medline]
PHST- 1992/12/15 00:00 [entrez]
AID - 0006-291X(92)92322-O [pii]
AID - 10.1016/0006-291x(92)92322-o [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1992 Dec 15;189(2):1136-42. doi: 
      10.1016/0006-291x(92)92322-o.