PMID- 1336470
OWN - NLM
STAT- MEDLINE
DCOM- 19930218
LR  - 20190827
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 100
IP  - 6
DP  - 1992 Dec
TI  - [Effects of suplatast tosilate (IPD-1151T) on antibody formations in mice].
PG  - 485-93
AB  - We examined the effects of suplatast tosilate (IPD-1151T) on antibody formation 
      in mice, and the following results were obtained: 1) IPD-1151T clearly increased 
      the productions of IgM and IgG-hemolytic plaque forming cells (PFC) in mice 
      immunized with sheep red blood cells (SRBC) when the agent was given p.o. for 5 
      days from the day of immunization. 2) IgM and IgG-PFC productions in old mice, 60 
      weeks of age, were clearly lower than those in adult mice, 10 weeks of age; and 
      an oral administration of IPD-1151T significantly recovered the decayed 
      PFC-production in the old mice. 3) IPD-1151T clearly suppressed the production of 
      anti-dinitrophenyl (DNP)-IgE antibody in mice when the agent was given p.o. for 5 
      days from the day of immunization, whereas the agent did not affect anti-DNP-IgM 
      and IgG antibody productions. 4) IPD-1151T did not affect the induction phase of 
      the cellular immune reaction of picryl chloride-induced contact dermatitis and 
      the SRBC-induced footpad reaction. Our present results suggest that IPD-1151T has 
      a class-specific suppressive effect on the production of IgE antibody, but does 
      not suppress the other immune responses.
FAU - Matsuura, N
AU  - Matsuura N
AD  - Department of Pharmacology, Gifu Pharmaceutical University, Japan.
FAU - Mori, H
AU  - Mori H
FAU - Nagai, H
AU  - Nagai H
FAU - Koda, A
AU  - Koda A
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Arylsulfonates)
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 0 (Sulfonium Compounds)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - C9J89787U1 (suplatast tosilate)
SB  - IM
MH  - Animals
MH  - Antibody Formation/*drug effects
MH  - Antibody-Producing Cells/immunology
MH  - Arylsulfonates/*pharmacology
MH  - Dinitrobenzenes/immunology
MH  - Erythrocytes/immunology
MH  - Female
MH  - Immunoglobulin E/biosynthesis
MH  - Immunoglobulin G/biosynthesis
MH  - Immunoglobulin M/biosynthesis
MH  - Male
MH  - Mice
MH  - Sheep
MH  - Sulfonium Compounds/*pharmacology
EDAT- 1992/12/01 00:00
MHDA- 1992/12/01 00:01
CRDT- 1992/12/01 00:00
PHST- 1992/12/01 00:00 [pubmed]
PHST- 1992/12/01 00:01 [medline]
PHST- 1992/12/01 00:00 [entrez]
AID - 10.1254/fpj.100.485 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 1992 Dec;100(6):485-93. doi: 10.1254/fpj.100.485.