PMID- 1336879
OWN - NLM
STAT- MEDLINE
DCOM- 19930225
LR  - 20151119
IS  - 0761-8425 (Print)
IS  - 0761-8425 (Linking)
VI  - 9 Suppl 4
DP  - 1992
TI  - [Do pathologic-anatomic data influence the staging of non-small cell bronchial 
      cancer?].
PG  - R309-15
AB  - The histopathology criteria which could be taken into account in devising the 
      best strategy in tumor extension search in non small cell lung carcinoma (NSCLC), 
      were examined. First, the differential diagnosis between primary and metastatic 
      carcinoma is impossible on histological basis in squamous carcinomas, and in 
      mucinous adenocarcinoma which share several features with tumors from digestive 
      tract including mucus secretion, morphological pattern and ultrastructural signs. 
      The recognition of cells which are unique in the lung (Clara cells, pneumonocytes 
      II) guarantees the pulmonary origin of a non mucinous adenocarcinoma. In other 
      cases such as large cell carcinomas, the diagnosis of metastasis can be achieved 
      in some instances in using a large panel of immunohistochemical markers. 
      Secondly, the expression of neuroendocrine markers in NSCLC could lead to an 
      extension search procedure identical to that of SCLC, if it can be confirmed that 
      they share their poor prognosis and chemosensibility. Finally, there is no 
      statistical evidence of a difference in the extrathoracic extension between well 
      and poorly differentiated forms of squamous carcinoma and adenocarcinoma. Only 
      one exception should be made for the recently described basaloid carcinoma of the 
      lung which extension and prognosis are more severe than in other NSCLC.
FAU - Brambilla, E
AU  - Brambilla E
AD  - Laboratoire d'Anatomie Pathologique, Hopital A.-Michallon, Grenoble.
LA  - fre
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Les donnees de l'anatomie pathologique influencent-elles le bilan d'extension du 
      cancer bronchique non a petites cellules?
PL  - France
TA  - Rev Mal Respir
JT  - Revue des maladies respiratoires
JID - 8408032
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Non-Small-Cell Lung/chemistry/*pathology/secondary
MH  - Humans
MH  - Lung Neoplasms/chemistry/*pathology
MH  - Neoplasm Staging
RF  - 34
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Rev Mal Respir. 1992;9 Suppl 4:R309-15.