PMID- 1337558
OWN - NLM
STAT- MEDLINE
DCOM- 19930316
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 50
IP  - 11
DP  - 1992 Nov
TI  - [Chronic fatigue syndrome and virus infection: human herpesvirus 6 (HHV-6) 
      infection].
PG  - 2612-6
AB  - Chronic fatigue syndrome (CFS) is newly-recognized disease characterized by 
      chronic and debilitating fatigue. It has been suggested that viral infection may 
      be involved in this syndrome from the results of clinical examination, including 
      increased activity of 2',5'-synthetase in leukocytes of patients. The following 
      viruses have been reported as etiologic agents of this disease. First, many 
      studies have found elevated levels of IgG to viral capsid antigen and early 
      antigens to Epstein-Barr virus (EBV), but low titer or absence of antibody to 
      EBV-associated nuclear antigen. Second, the enteroviruses have also been 
      implicated as possible causative agent of CFS, because virus could be isolated 
      from patients. Recently it was also reported that antibodies to human 
      T-lymphotropic virus (HTLV) and HTLV type II (HTLV-II) gag sequence were 
      detectable in patients. Finally several reports state that human herpesvirus 6 
      (HHV-6) could be isolated from CFS patients in the high frequency. In conclusion, 
      it is still early to identify the etiologic agent from these reports, and more 
      effort is needed.
FAU - Yamanishi, K
AU  - Yamanishi K
AD  - Research Institute for Microbial Diseases, Osaka University.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Fatigue Syndrome, Chronic/*etiology
MH  - Herpesviridae Infections/*complications/diagnosis
MH  - *Herpesvirus 6, Human/immunology
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Immunoglobulin M/analysis
MH  - Virus Activation
RF  - 19
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1992 Nov;50(11):2612-6.