PMID- 1337798
OWN - NLM
STAT- MEDLINE
DCOM- 19930324
LR  - 20190606
IS  - 1010-4283 (Print)
IS  - 1010-4283 (Linking)
VI  - 13
IP  - 5-6
DP  - 1992
TI  - Coexpression of ganglioside antigen Fuc-GM1, neural-cell adhesion molecule, 
      carcinoembryonic antigen, and carbohydrate tumor-associated antigen CA 50 in lung 
      cancer.
PG  - 308-15
AB  - With the aid of specific monoclonal antibodies, tumor tissues from 68 patients 
      with lung cancer were examined for their expression of two small cell lung 
      carcinoma (SCLC) antigens, Fuc-GM1 (fucosyl GM1; IV2FucII3NeuAc GgOse4) and 
      neural-cell adhesion molecule (NCAM), and two broader tumor antigens, 
      carcinoembryonic antigen (CEA) and carbohydrate cancer-associated antigen CA 50. 
      Expression of Fuc-GM1 was seen in 75% and NCAM in 78% of the SCLC specimens, but 
      also in 12 and 20% of non-SCLC. Either or both of these antigens were expressed 
      in more than 90% of SCLC and in 25% of non-SCLC. CEA was found in more than 80% 
      of SCLC and non-SCLC. Expression of CA 50 was seen in 65-68% of non-SCLC and 
      SCLC, showing preference for SCLC and lung adenocarcinoma. In SCLC, cellular 
      expression of Fuc-GM1 was generally seen together with NCAM and CA 50, but rarely 
      with CEA. There was considerable inter- and intratumor heterogeneity in the 
      expression of all four antigens. The results suggest that CEA is the antigen of 
      choice for the detection of lung cancer regardless of histotype. In combined 
      analysis of CEA, CA 50, Fuc-GM1 and NCAM, two patterns of antigen expression were 
      recognized that appear to discriminate between SCLC and non-SCLC tumors, 
      respectively. A considerable fraction of SCLC and non-SCLC tumors, however, 
      exhibited similar patterns of antigen expression. The biological and clinical 
      significance of these observations remains to be investigated.
FAU - Brezicka, F T
AU  - Brezicka FT
AD  - Department of Medical Microbiology and Immunology, University of Goteborg, 
      Sweden.
FAU - Olling, S
AU  - Olling S
FAU - Bergman, B
AU  - Bergman B
FAU - Berggren, H
AU  - Berggren H
FAU - Engstrom, C P
AU  - Engstrom CP
FAU - Hammarstrom, S
AU  - Hammarstrom S
FAU - Holmgren, J
AU  - Holmgren J
FAU - Larsson, S
AU  - Larsson S
FAU - Lindholm, L
AU  - Lindholm L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Tumor-Associated, Carbohydrate)
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 37758-47-7 (G(M1) Ganglioside)
RN  - 71812-11-8 (fucosyl GM1 ganglioside)
SB  - IM
MH  - Antibodies, Monoclonal
MH  - Antibody Specificity
MH  - Antigens, Neoplasm/*analysis
MH  - Antigens, Tumor-Associated, Carbohydrate/analysis
MH  - Carcinoembryonic Antigen/analysis
MH  - Carcinoma, Non-Small-Cell Lung/diagnosis/*immunology
MH  - Carcinoma, Small Cell/diagnosis/*immunology
MH  - Cell Adhesion Molecules, Neuronal/analysis
MH  - Diagnosis, Differential
MH  - G(M1) Ganglioside/*analogs & derivatives/*therapeutic use
MH  - Humans
MH  - Immunization
MH  - Immunohistochemistry
MH  - Lung Neoplasms/*immunology
EDAT- 1992/01/01 00:00
MHDA- 2000/03/01 00:00
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 2000/03/01 00:00 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000217780 [doi]
PST - ppublish
SO  - Tumour Biol. 1992;13(5-6):308-15. doi: 10.1159/000217780.