PMID- 1338487
OWN - NLM
STAT- MEDLINE
DCOM- 19930513
LR  - 20061115
IS  - 0412-3948 (Print)
IS  - 0412-3948 (Linking)
VI  - 27
IP  - 4
DP  - 1992
TI  - [Detection of HPV-16-related DNA sequence in laryngeal squamous cell carcinoma].
PG  - 241-2, 256
AB  - The gene libraries of laryngeal squamous cell carcinoma (LSCC) and laryngeal 
      papilloma (LP) were screened by hybridization analysis with alpha-32P-labelled 
      HPV-16 DNA under low stringency (Tm = 40 degrees C). It showed that the relative 
      sequences were detected in LSCCs (11/16, 68.8%), but not in LP. The 
      HPV-16-related DNA harbored in negative hybridization lesions were further 
      analysed by polymerase chain reaction to amplify E6/E7 gene of HPV-16-related 
      DNA. The results showed that 1/5 LSCCs and 2/2 LPs, were positive. The data 
      suggest that development of LSCC should be related to the HPV infection, and HPV 
      may be one of the inducers of LSCC.
FAU - Yao, C D
AU  - Yao CD
AD  - Second Affiliated Hospital, Hubei Medical College, Wuhan.
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Ke Za Zhi
JT  - Zhonghua er bi yan hou ke za zhi
JID - 16210350R
RN  - 0 (DNA Probes)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Base Sequence
MH  - Carcinoma, Squamous Cell/genetics/*microbiology
MH  - DNA Probes
MH  - DNA, Viral/*genetics
MH  - Humans
MH  - Immunoblotting
MH  - Laryngeal Neoplasms/genetics/*microbiology
MH  - Molecular Sequence Data
MH  - Papillomaviridae/genetics/*isolation & purification
MH  - Polymerase Chain Reaction
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Ke Za Zhi. 1992;27(4):241-2, 256.