PMID- 1338733
OWN - NLM
STAT- MEDLINE
DCOM- 19930528
LR  - 20131121
IS  - 0141-9846 (Print)
IS  - 0141-9846 (Linking)
VI  - 18
IP  - 3
DP  - 1992 Sep
TI  - The effect of chronic and acute haemorrhage on erythropoietin in the neonatal 
      lamb.
PG  - 129-36
AB  - In all mammalian species studied the haematocrit (hct) declines after birth in 
      the absence of any known nutritional deficiencies. The glycoprotein hormone, 
      erythropoietin (Epo), is essential for normal red blood cell production. The aims 
      of this study were 1) to investigate the changes in plasma Epo during the normal 
      post-natal decrease in hct in lambs; 2) to compare the effects of chronic and 
      acute haemorrhage in neonatal lambs; and 3) to test the hypothesis that the Epo 
      response to haemorrhage is blunted in the neonatal period. Twenty-one lambs (0-9 
      weeks of age) were studied; group I (n = 8) were used to document normal 
      post-natal changes (98 samples); group II (n = 7) lambs were haemorrhaged 
      repetitively during weeks 3-6 (95 samples); group III (n = 6) lambs were bled 
      once in the first 3-week period. In the group I (control lambs) the hct decreased 
      from 30.6 +/- 1.3 (weeks 1 & 2) to a nadir of 23.2 +/- 0.8 (75.8% of initial 
      value) in the 6th week, and the plasma Epo declined from 25.7 +/- 4.9 (week 1) to 
      12.3 +/- 1.0 mU/ml (week 6). In group II, the lambs were bled repetitively, a 
      total of 510 +/- 32 ml blood being removed during weeks 3-6, the hct was 18.7 +/- 
      0.8 (81% of hct at nadir in controls) in week 6, and Epo was 26.9 +/- 13.3 in 
      week 3, 23.4 +/- 3.6 mU/ml in week 6.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Moritz, K M
AU  - Moritz KM
AD  - Howard Florey Institute of Experimental Physiology and Medicine, University of 
      Melbourne, Parkville, Victoria, Australia.
FAU - Clemons, G
AU  - Clemons G
FAU - Tangalakis, K
AU  - Tangalakis K
FAU - Wintour, E M
AU  - Wintour EM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Dev Physiol
JT  - Journal of developmental physiology
JID - 7910737
RN  - 11096-26-7 (Erythropoietin)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9004-22-2 (Globins)
RN  - S88TT14065 (Oxygen)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Acute Disease
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Animals, Newborn/*blood/growth & development
MH  - Carbon Dioxide/blood
MH  - Chronic Disease
MH  - Erythropoietin/*blood
MH  - Globins/analysis/chemistry
MH  - Hematocrit
MH  - Hemorrhage/*blood
MH  - Hydrocortisone/blood
MH  - Oxygen/blood
MH  - Reference Values
MH  - Sheep
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
PST - ppublish
SO  - J Dev Physiol. 1992 Sep;18(3):129-36.