PMID- 1338784
OWN - NLM
STAT- MEDLINE
DCOM- 19930604
LR  - 20181130
IS  - 0141-9846 (Print)
IS  - 0141-9846 (Linking)
VI  - 18
IP  - 4
DP  - 1992 Oct
TI  - Prostaglandin E2 stimulates adrenocorticotrophin and cortisol secretion via a 
      hypothalamic site of action in fetal sheep.
PG  - 173-7
AB  - The hypothesis that prostaglandins stimulate fetal adrenocortical activity via a 
      central site of action within the fetal brain was tested in chronically 
      catheterized fetal sheep. At day 120 gestation (term = 145 days) fetal sheep were 
      surgically prepared with catheters in the lateral cerebral ventricle, jugular 
      vein and carotid artery and experiments began five days later. Intravenous (i.v.) 
      infusion of prostaglandin E2 (30 or 120 micrograms.h-1) caused a significant 
      dose-related increase in fetal plasma concentrations of ACTH. Despite this 
      increase in ACTH, cortisol was only stimulated after the highest dose of 
      prostaglandin E2. Intracerebroventricular (i.c.v.) infusion of PGE2 (30 
      micrograms.h-1) also stimulated ACTH secretion although the peak response was 
      delayed and considerably less compared with the same dose administered 
      intravenously. Prostaglandin F2 alpha administered i.v. or i.c.v. had no effect 
      on circulating concentrations of either ACTH or cortisol. These data provide 
      evidence that prostaglandin E2 can stimulate fetal ACTH secretion by acting in 
      the fetal brain. Furthermore, the greater release of ACTH after i.v. compared 
      with i.c.v. prostaglandin E2 suggests that a site of action other than the brain, 
      such as the pituitary gland, may also be important. These results provide further 
      evidence that during late gestation circulating prostaglandins can act to 
      stimulate fetal pituitary-adrenal maturation.
FAU - Brooks, A N
AU  - Brooks AN
AD  - MRC Reproductive Biology Unit, Edinburgh, Scotland.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Dev Physiol
JT  - Journal of developmental physiology
JID - 7910737
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood/*metabolism
MH  - Animals
MH  - Dinoprostone/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Fetal Blood/metabolism
MH  - Fetus/*physiology
MH  - Hydrocortisone/blood/*metabolism
MH  - Hypothalamus/drug effects/*physiology
MH  - Infusions, Intravenous
MH  - Injections, Intraventricular
MH  - Osmolar Concentration
MH  - Sheep
MH  - Time Factors
EDAT- 1992/10/01 00:00
MHDA- 1992/10/01 00:01
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 1992/10/01 00:01 [medline]
PHST- 1992/10/01 00:00 [entrez]
PST - ppublish
SO  - J Dev Physiol. 1992 Oct;18(4):173-7.