PMID- 1339196
OWN - NLM
STAT- MEDLINE
DCOM- 19930930
LR  - 20131121
IS  - 0023-1924 (Print)
IS  - 0023-1924 (Linking)
VI  - 65
IP  - 2-3
DP  - 1992 Sep
TI  - Protective effects of thiol containing chelating agents against liver injury 
      induced by hexavalent chromium in mice.
PG  - 87-96
AB  - The effects of the chelating agents, L-cysteine ethyl ester (LCEE), L-cysteine 
      methyl ester (LCME), N-acetyl-L-(+)-cysteine (NAC), 
      2,3-dimercapto-1-propanesulfonic acid (DMPS), N-(2-mercaptopropionyl)-glycine 
      (MPG), and 2,3-dimercaptosuccinic acid (DMSA), on the distribution, excretion and 
      hepatotoxicity of ip injected hexavalent chromium were studied in male mice. The 
      chelating agents (500 mg/kg) were injected iv as single doses given immediately 
      or 30 min after potassium dichromate (20 mg Cr/kg) as hexavalent chromium was 
      administered. When the chelating agents were injected immediately after the metal 
      compound was administered, LCEE, LCME, NAC, DMPS, and MPG reduced the chromium 
      contents in the liver and kidney, and facilitated the urinary excretion of 
      chromium. The liver injury induced by chromium, which was evaluated by serum 
      ornithine carbamyl transferase (OCT) activity, was prevented significantly by 
      LCEE, LCME, DMPS, and MPG. On the other hand, when these chelating agents were 
      injected at 30 min after the chromium administration, only DMSA could prevent the 
      liver injury induced by the metal, and decreased the chromium contents in the 
      liver. However, when DMSA was given at 3 hr after the metal administration, there 
      was no therapeutic effect on them. These results suggest that the chelating 
      agents tested may be useful in the treatment of intoxications due to hexavalent 
      chromium, but there is the difference in the therapeutic effects of the chelating 
      agents owing to the time intervals after the administration of the metal.
FAU - Ueno, S
AU  - Ueno S
AD  - Department of Veterinary Public Health, School of Veterinary Medicine and Animal 
      Sciences, Kitasato University, Aomori, Japan.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Kitasato Arch Exp Med
JT  - The Kitasato archives of experimental medicine
JID - 0376613
RN  - 0 (Chelating Agents)
RN  - 0 (Chromates)
RN  - 0 (Sulfhydryl Compounds)
RN  - DX1U2629QE (Succimer)
SB  - IM
MH  - Animals
MH  - Chelating Agents/*pharmacology
MH  - Chromates/metabolism/*toxicity
MH  - Liver/*drug effects
MH  - Male
MH  - Mice
MH  - Succimer/pharmacology
MH  - Sulfhydryl Compounds/*pharmacology
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
PST - ppublish
SO  - Kitasato Arch Exp Med. 1992 Sep;65(2-3):87-96.