PMID- 1341072
OWN - NLM
STAT- MEDLINE
DCOM- 19940106
LR  - 20220311
IS  - 0044-0086 (Print)
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Linking)
VI  - 65
IP  - 6
DP  - 1992 Nov-Dec
TI  - Roles for transforming growth factor-alpha in gastric physiology and 
      pathophysiology.
PG  - 693-704; discussion 621-3
AB  - Transforming growth factor alpha (TGF alpha) is a 5.6 kd single-chain polypeptide 
      that acts through binding to the epidermal growth factor receptor (EGFR). TGF 
      alpha is produced in a wide range of normal as well as embryonic and neoplastic 
      cells and tissues. TGF alpha and EGFR, but not EGF, are expressed in normal 
      gastric mucosa. We have identified the following biological roles for TGF alpha 
      in the stomach, using a variety of primate and rodent models: inhibition of acid 
      secretion; stimulation of mucous cell growth; protection against ethanol- and 
      aspirin-induced injury. This last effect is associated with a time- and 
      dose-dependent increase in levels of insoluble gastric mucin. Based on these 
      known biological actions of TGF alpha, we have examined TGF alpha production in 
      Menetrier's disease, a disorder characterized by foveolar hyperplasia, 
      hypochlorhydria, and increased gastric mucin content. In four patients with 
      Menetrier's disease, there was enhanced TGF alpha immunostaining throughout the 
      gastric mucosa. Furthermore, metallothionein (MT)-TGF alpha transgenic mice which 
      overproduce TGF alpha in the stomach exhibit histopathological and biochemical 
      features characteristic of and consistent with the diagnosis of Menetrier's 
      disease. Thus locally produced TGF alpha may mediate a number of biological 
      processes in the stomach, and its altered production may participate in the 
      pathogenesis of selected pathological states.
FAU - Coffey, R J
AU  - Coffey RJ
AD  - Department of Medicine and Cell Biology, Vanderbilt University, Nashville, 
      Tennessee 37232.
FAU - Romano, M
AU  - Romano M
FAU - Polk, W H
AU  - Polk WH
FAU - Dempsey, P J
AU  - Dempsey PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Gastric Mucosa/chemistry/physiology/physiopathology
MH  - Humans
MH  - Molecular Sequence Data
MH  - Stomach/chemistry/*physiology/*physiopathology
MH  - Stomach Diseases/etiology/physiopathology
MH  - Transforming Growth Factor alpha/analysis/chemistry/*physiology
PMC - PMC2589761
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
PMCR- 1992/11/01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
PST - ppublish
SO  - Yale J Biol Med. 1992 Nov-Dec;65(6):693-704; discussion 621-3.