PMID- 1341076
OWN - NLM
STAT- MEDLINE
DCOM- 19940106
LR  - 20181113
IS  - 0044-0086 (Print)
IS  - 1551-4056 (Electronic)
IS  - 0044-0086 (Linking)
VI  - 65
IP  - 6
DP  - 1992 Nov-Dec
TI  - Praomys (Mastomys) natalensis: a model for gastric carcinoid formation.
PG  - 741-51; discussion 827-9
AB  - The gastric carcinoid tumors of Praomys (Mastomys) natalensis have been reviewed 
      with respect to histogenesis, development, biochemistry, and morphological 
      properties. Multicentric gastric carcinoids frequently develop in the oxyntic 
      mucosa of aging Mastomys. The development of these tumors can be significantly 
      enhanced by drug-induced hypergastrinemia, e.g., histamine2-receptor blockade. 
      Spontaneous and drug-induced gastric carcinoids are endocrine in nature, as 
      evidenced by their argyrophilic staining properties and chromogranin A content. 
      They are also rich in histidine decarboxylase activity and produce large amounts 
      of histamine, although other hormones, such as peptide YY and enteroglucagon, 
      have also been demonstrated in these tumors. Ultrastructurally, gastric 
      carcinoids are composed of tumor cells with typical secretory granules resembling 
      those of enterochromaffin-like (ECL) cells. A close examination of the gastric 
      carcinoids in Mastomys reveals striking similarities with gastric carcinoids 
      developing in humans suffering from chronic atrophic gastritis type A or from the 
      Zollinger-Ellison syndrome in combination with multiple endocrine neoplasia type 
      1 (MEN-1). Both these conditions are associated with hypergastrinemia and a 
      higher risk for developing multi-centric gastric carcinoids of ECL-cell origin. 
      The Mastomys tumor model therefore appears to be a significant experimental model 
      in which induction and formation of gastric carcinoid tumors can be studied.
FAU - Nilsson, O
AU  - Nilsson O
AD  - Department of Histology, University of Goteborg, Sweden.
FAU - Wangberg, B
AU  - Wangberg B
FAU - Johansson, L
AU  - Johansson L
FAU - Modlin, I M
AU  - Modlin IM
FAU - Ahlman, H
AU  - Ahlman H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Yale J Biol Med
JT  - The Yale journal of biology and medicine
JID - 0417414
SB  - IM
MH  - Animals
MH  - Carcinoid Tumor/etiology/*pathology
MH  - Cell Transformation, Neoplastic/*pathology
MH  - Disease Models, Animal
MH  - Humans
MH  - *Muridae
MH  - Stomach Neoplasms/etiology/*pathology
PMC - PMC2589773
EDAT- 1992/11/01 00:00
MHDA- 1992/11/01 00:01
PMCR- 1992/11/01
CRDT- 1992/11/01 00:00
PHST- 1992/11/01 00:00 [pubmed]
PHST- 1992/11/01 00:01 [medline]
PHST- 1992/11/01 00:00 [entrez]
PHST- 1992/11/01 00:00 [pmc-release]
PST - ppublish
SO  - Yale J Biol Med. 1992 Nov-Dec;65(6):741-51; discussion 827-9.