PMID- 1342064
OWN - NLM
STAT- MEDLINE
DCOM- 19940201
LR  - 20191028
IS  - 0736-0118 (Print)
IS  - 0736-0118 (Linking)
VI  - 9
IP  - 4
DP  - 1992
TI  - The monocyte tumor necrosis factor-alpha production in patients with acute 
      leukemia in complete remission.
PG  - 191-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) production by unstimulated and 
      lipopolysaccharide (LPS)-stimulated peripheral monocytes has been studied in 17 
      acute myeloid leukemia (AML) patients, 54 AML patients in complete remission 
      (AML-CR), 9 acute lymphoblastic leukemia (ALL) patients and 13 ALL patients in 
      complete remission (ALL-CR). TNF-alpha production by the unstimulated monocytes 
      in ALL patients (n = 6, mean: 6.6 +/- 4.9 u/ml) was higher than that of normal 
      controls (n = 13, 0.9 +/- 0.7 u/ml), AML patients (n = 14, 2.0 +/- 2.1 u/ml) and 
      AML-CR patients (n = 21, 1.4 +/- 1.2 u/ml). TNF-alpha production by the 
      LPS-stimulated monocytes of the AML-CR patients (n = 54, 12.4 +/- 13.4 u/ml) was 
      significantly higher than that of the normal controls (n = 21, 3.5 +/- 2.5 u/ml) 
      and the AML patients (n = 17, 2.6 +/- 2.4 u/ml), p < 0.01, but there were not any 
      significant differences among the AML-CR patients and the ALL patients or the 
      ALL-CR patients. We separated the AML-CR patients into 3 groups, depending on the 
      length of their remission, and found that AML-CR patients with longer than 6 
      months (M) but less than 60 M (n = 21, 15.7 +/- 16.9 u/ml) and the patients with 
      a remission longer than 60 M (n = 11, 18.2 +/- 15.9 u/ml) had significantly 
      higher TNF-alpha production than that of the controls.(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Aiso, M
AU  - Aiso M
AD  - First Department of Internal Medicine, Nihon University School of Medicine, 
      Tokyo, Japan.
FAU - Iizuka, Y
AU  - Iizuka Y
FAU - Kang, H I
AU  - Kang HI
FAU - Sawada, S
AU  - Sawada S
FAU - Ohshima, T
AU  - Ohshima T
FAU - Horie, T
AU  - Horie T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Med Oncol Tumor Pharmacother
JT  - Medical oncology and tumor pharmacotherapy
JID - 8405039
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid/*blood
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/drug effects/*metabolism
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*blood
MH  - Remission Induction
MH  - Stimulation, Chemical
MH  - Tumor Necrosis Factor-alpha/*biosynthesis
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1007/BF02987756 [doi]
PST - ppublish
SO  - Med Oncol Tumor Pharmacother. 1992;9(4):191-7. doi: 10.1007/BF02987756.