PMID- 1347328
OWN - NLM
STAT- MEDLINE
DCOM- 19920409
LR  - 20181130
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 50
IP  - 1
DP  - 1992 Jan
TI  - [Investigation of the therapeutic use of proton pump inhibitor (PPI) by 
      measurement of 24 hour the intra-gastric pH].
PG  - 160-6
AB  - The intragastric acidic condition were examined over 24 hours in 13 healthy 
      volunteers to compare the inhibitory effect of PPI and of H2-antagonist on the 
      acid secretion. Both PPI 15 mg and PPI 20 mg showed a stronger action on the acid 
      inhibition than H2-antagonists. The morning PPI (20 mg) administration inhibited 
      the acid secretion from noon the first day, and showed an even stronger effect on 
      the fourth day (total PPI 80 mg). Evening PPI administration showed poorer 
      effects than the morning. However, of this was due to a difference in the 
      inhibitory effect in the daytime. The evening PPI administration showed effective 
      acid inhibition at night, and nocturnal intra-gastric pH inversion appeared. It 
      is suggested that the evening PPI administration is more suitable both the 
      ulcer-healing and food digestion in the curative stage.
FAU - Yamagata, S
AU  - Yamagata S
AD  - Department of Internal Medicine, University of Tsukuba.
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
RN  - 0 (Histamine H2 Antagonists)
RN  - EC 3.6.1.- (Adenosine Triphosphatases)
RN  - EC 3.6.3.10 (H(+)-K(+)-Exchanging ATPase)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - Adenosine Triphosphatases/antagonists & inhibitors
MH  - Adult
MH  - Circadian Rhythm
MH  - Depression, Chemical
MH  - Gastric Acid/*metabolism
MH  - *Gastric Acidity Determination
MH  - H(+)-K(+)-Exchanging ATPase
MH  - Histamine H2 Antagonists/pharmacology
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Monitoring, Physiologic
MH  - Omeprazole/*administration & dosage/pharmacology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1992 Jan;50(1):160-6.