PMID- 1347336
OWN - NLM
STAT- MEDLINE
DCOM- 19920409
LR  - 20190610
IS  - 0140-6736 (Print)
IS  - 0140-6736 (Linking)
VI  - 339
IP  - 8794
DP  - 1992 Mar 14
TI  - Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of 
      gastric cancer.
PG  - 629-31
AB  - Attempts to prevent peritoneal carcinomatosis after surgery for gastric cancer by 
      intraperitoneal administration of anticancer drugs have not been successful, 
      largely because the drugs are not retained in the peritoneal cavity. We have 
      assessed the prophylactic efficacy of a delayed-release preparation--mitomycin 
      adsorbed onto activated charcoal (M-CH). 50 patients with gastric cancer and 
      serosal infiltration were randomly assigned intraperitoneal treatment with M-CH 
      (50 mg mitomycin intraoperatively) or no anticancer prophylaxis (control). 
      Survival rates for the 3 years of follow-up were significantly higher among the 
      24 M-CH recipients (1 was lost to follow-up) than among the 25 controls (p less 
      than 0.01). There were significant differences in survival between the groups at 
      1.5 years after randomisation (difference 34.6% [95% confidence interval 
      8.5-60.8%]; p less than 0.01) and at 2.0, 2.5, and 3.0 years (41.7% [14.2-69.1%]; 
      p less than 0.005). The concentration of mitomycin was significantly higher in 
      peritoneal exudate than in plasma for 24 h after drug administration. 
      Side-effects were slight and well tolerated. Thus, peroperative intraperitoneal 
      treatment with M-CH seems to improve survival after gastrectomy for gastric 
      cancer, presumably by a prophylactic effect on peritoneal recurrence.
FAU - Hagiwara, A
AU  - Hagiwara A
AD  - First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
FAU - Takahashi, T
AU  - Takahashi T
FAU - Kojima, O
AU  - Kojima O
FAU - Sawai, K
AU  - Sawai K
FAU - Yamaguchi, T
AU  - Yamaguchi T
FAU - Yamane, T
AU  - Yamane T
FAU - Taniguchi, H
AU  - Taniguchi H
FAU - Kitamura, K
AU  - Kitamura K
FAU - Noguchi, A
AU  - Noguchi A
FAU - Seiki, K
AU  - Seiki K
AU  - et al.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lancet
JT  - Lancet (London, England)
JID - 2985213R
RN  - 0 (Mitomycins)
RN  - 16291-96-6 (Charcoal)
SB  - IM
CIN - Lancet. 1992 Jun 27;339(8809):1608. PMID: 1351577
MH  - Adsorption
MH  - Adult
MH  - Aged
MH  - Charcoal/administration & dosage
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitomycins/administration & dosage/*therapeutic use
MH  - Neoplasm Recurrence, Local/prevention & control
MH  - Peritoneal Neoplasms/mortality/*prevention & control
MH  - Stomach Neoplasms/mortality/*therapy
MH  - Survival Analysis
EDAT- 1992/03/14 00:00
MHDA- 1992/03/14 00:01
CRDT- 1992/03/14 00:00
PHST- 1992/03/14 00:00 [pubmed]
PHST- 1992/03/14 00:01 [medline]
PHST- 1992/03/14 00:00 [entrez]
AID - 0140-6736(92)90792-2 [pii]
AID - 10.1016/0140-6736(92)90792-2 [doi]
PST - ppublish
SO  - Lancet. 1992 Mar 14;339(8794):629-31. doi: 10.1016/0140-6736(92)90792-2.