PMID- 1348518
OWN - NLM
STAT- MEDLINE
DCOM- 19920513
LR  - 20220227
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 148
IP  - 8
DP  - 1992 Apr 15
TI  - Monocyte chemoattractant protein-1 regulates adhesion molecule expression and 
      cytokine production in human monocytes.
PG  - 2423-8
AB  - Monocytes play a critical role in defending the host against foreign organisms 
      and in regulating the behavior of other cells. Monocytes circulate as nonadherent 
      cells in the blood and migrate as adherent cells through tissues. Adhesion 
      molecules mediate not only cell adhesion, but also migration, phagocytosis, and 
      many other adhesion-dependent functions. Monocyte chemoattractant protein-1 
      (MCP-1) is thought to be responsible for monocyte recruitment in acute 
      inflammatory conditions and may be an important mediator in chronic inflammation. 
      In this study, immunofluorescence flow cytometry was used to determine whether 
      MCP-1 can regulate the cell surface expression of adhesion molecules, 
      particularly beta-2 and alpha-4 integrins and the leukocyte adhesion molecule-1. 
      We found that MCP-1 induced expression of CD11c (p150,95 alpha-subunit) and CD11b 
      (Mac-1 alpha-subunit), and caused little or no change of CD11a (lymphocyte 
      function-associated Ag-1 alpha-subunit), very late activation Ag-4, or leukocyte 
      adhesion molecule-1. We demonstrated that antibodies to beta-2 and alpha-4 
      integrins inhibited MCP-1-induced monocyte chemotaxis. We also showed that MCP-1 
      is capable of inducing IL-1 and IL-6, but not TNF production of monocytes. These 
      results indicate that MCP-1 is not only a chemoattractant but also a novel 
      cytokine with the capacity to regulate several parameters of monocyte function.
FAU - Jiang, Y
AU  - Jiang Y
AD  - Department of Oral Biology, Boston University Medical Center, MA 02118.
FAU - Beller, D I
AU  - Beller DI
FAU - Frendl, G
AU  - Frendl G
FAU - Graves, D T
AU  - Graves DT
LA  - eng
GR  - DE07559/DE/NIDCR NIH HHS/United States
GR  - DE08569/DE/NIDCR NIH HHS/United States
GR  - DE0958/DE/NIDCR NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antigens, CD)
RN  - 0 (CD11 Antigens)
RN  - 0 (CD18 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (Integrins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Antigens, CD/*analysis
MH  - CD11 Antigens
MH  - CD18 Antigens
MH  - Cells, Cultured
MH  - Chemokine CCL2
MH  - Chemotactic Factors/*pharmacology
MH  - Chemotaxis, Leukocyte/drug effects
MH  - Cytokines/*biosynthesis
MH  - Humans
MH  - Integrins/physiology
MH  - Interleukin-1/biosynthesis
MH  - Interleukin-6/biosynthesis
MH  - Monocytes/*drug effects/physiology
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
EDAT- 1992/04/15 00:00
MHDA- 1992/04/15 00:01
CRDT- 1992/04/15 00:00
PHST- 1992/04/15 00:00 [pubmed]
PHST- 1992/04/15 00:01 [medline]
PHST- 1992/04/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1992 Apr 15;148(8):2423-8.