PMID- 1349556
OWN - NLM
STAT- MEDLINE
DCOM- 19920609
LR  - 20190819
IS  - 0309-0167 (Print)
IS  - 0309-0167 (Linking)
VI  - 20
IP  - 4
DP  - 1992 Apr
TI  - Parathyroid hyperplasia in multiple endocrine neoplasia type 1: a pathological 
      and immunohistochemical reappraisal.
PG  - 305-13
AB  - Twenty-nine parathyroid glands from nine patients with multiple endocrine 
      neoplasia type 1 (MEN 1) syndrome were examined histopathologically and 
      immunocytochemically to characterize better the nature of the accompanying 
      parathyroid hyperplasia. The parathyroids showed varying degrees of nodular and 
      diffuse (partial and total) hyperplastic involvement as well as apparently normal 
      tissue. The nodules were usually multiple within any one gland and showed a 
      varied cytoarchitectural pattern. All glands studied showed both cellular 
      argyrophilia and parathyroid hormone immunoreactivity. The staining pattern for 
      parathyroid hormone ranged from negative or weak to strong and from patchy to 
      diffuse in hyperplastic tissue from different glands and within the same gland. 
      Apparently normal areas usually showed the strongest positive reaction. Amyloid 
      material was observed within glandular lumens from hyperplastic areas in over 
      half of the studied cases and stained positively for parathyroid hormone. This 
      suggests that the hormone could be the precursor molecule of parathyroid amyloid 
      as occurs with hormone-derived amyloid from other endocrine tumours. The overall 
      findings indicate that the most striking feature of the parathyroid glands in MEN 
      1 is their variability, both morphological and functional, as indicated by their 
      parathyroid hormone immunoreactivity.
FAU - Harach, H R
AU  - Harach HR
AD  - Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
FAU - Jasani, B
AU  - Jasani B
LA  - eng
PT  - Journal Article
PL  - England
TA  - Histopathology
JT  - Histopathology
JID - 7704136
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Hyperplasia
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/chemistry/*pathology
MH  - Parathyroid Neoplasms/chemistry/*pathology
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
AID - 10.1111/j.1365-2559.1992.tb00987.x [doi]
PST - ppublish
SO  - Histopathology. 1992 Apr;20(4):305-13. doi: 10.1111/j.1365-2559.1992.tb00987.x.