PMID- 1349571
OWN - NLM
STAT- MEDLINE
DCOM- 19920605
LR  - 20190902
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 13
IP  - 1
DP  - 1992 May
TI  - A 14-Mb physical map of the region at chromosome 11q13 harboring the MEN1 locus 
      and the tumor amplicon region.
PG  - 16-20
AB  - We have constructed a physical map of chromosome 11q13, using 54 DNA markers that 
      had been localized to 11q13.1----q13.5 by means of somatic hybrid cell panels. 
      Although the map has some gaps, it spans nearly 14 Mb and includes the region 
      containing the gene responsible for multiple endocrine neoplasia type 1 (MEN1) 
      and also the region that is amplified in several types of malignant tumors. As 
      the estimated average distance between each locus is roughly 300 kb, the markers 
      reported here will be valuable resources for construction of contig maps with 
      yeast artificial chromosomes and/or cosmid clones. Furthermore, these clones will 
      be useful in efforts to identify the MEN1 gene and in analyses of the 
      amplification units present at 11q13 in certain tumors.
FAU - Tanigami, A
AU  - Tanigami A
AD  - Division of Biochemistry, Cancer Institute, Tokyo, Japan.
FAU - Tokino, T
AU  - Tokino T
FAU - Takita, K
AU  - Takita K
FAU - Takiguchi, S
AU  - Takiguchi S
FAU - Nakamura, Y
AU  - Nakamura Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Genetic Markers)
SB  - IM
GS  - MEN1
MH  - Blotting, Southern
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - *Gene Amplification
MH  - Genetic Markers/*genetics
MH  - Humans
MH  - Hybrid Cells
MH  - Multiple Endocrine Neoplasia/*genetics
EDAT- 1992/05/01 00:00
MHDA- 1992/05/01 00:01
CRDT- 1992/05/01 00:00
PHST- 1992/05/01 00:00 [pubmed]
PHST- 1992/05/01 00:01 [medline]
PHST- 1992/05/01 00:00 [entrez]
AID - 10.1016/0888-7543(92)90195-x [doi]
PST - ppublish
SO  - Genomics. 1992 May;13(1):16-20. doi: 10.1016/0888-7543(92)90195-x.