PMID- 1350336
OWN - NLM
STAT- MEDLINE
DCOM- 19920625
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 134
IP  - 2
DP  - 1992 Jan 6
TI  - Reversal by pertussis toxin and N-ethylmaleimide of the facilitation of 
      baroreceptor reflex response by somatostatin in the rat.
PG  - 267-70
AB  - We evaluated the transmembrane signaling mechanism that may underlie the 
      facilitatory action of somatostatin (SOM) on baroreceptor reflex (BRR), using 
      adult, male, Sprague-Dawley rats anesthetized with pentobarbital sodium (40 
      mg/kg, i.p.). Intracerebroventricular (i.c.v.) application of SOM (2 nmol) 
      promoted a significant elevation in BRR response, induced by phenylephrine (5 
      micrograms/kg, i.v.). This potentiatory action of the tetradecapeptide was 
      significantly reversed after pretreating animals with bilateral microinjection of 
      pertussis toxin (25 ng) or N-ethylmaleimide (2 nmol) into the nucleus tractus 
      solitarius (NTS), the terminal site for baroreceptor afferents. These results 
      suggest that a pertussis toxin-sensitive GTP-binding regulatory protein, possibly 
      Gi, may be involved in the modulation of the BRR by SOM at the NTS.
FAU - Chan, J Y
AU  - Chan JY
AD  - Department of Medical Research, Veterans General Hospital-Taipei, Taiwan, 
      Republic of China.
FAU - Lin, S S
AU  - Lin SS
FAU - Chan, S H
AU  - Chan SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Virulence Factors, Bordetella)
RN  - 1WS297W6MV (Phenylephrine)
RN  - 51110-01-1 (Somatostatin)
RN  - EC 2.4.2.31 (Pertussis Toxin)
RN  - O3C74ACM9V (Ethylmaleimide)
SB  - IM
MH  - Afferent Pathways/drug effects/physiology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Ethylmaleimide/administration & dosage/*pharmacology
MH  - Heart Rate/*drug effects
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Medulla Oblongata/drug effects/*physiology
MH  - Microinjections
MH  - *Pertussis Toxin
MH  - Phenylephrine/administration & dosage/pharmacology
MH  - Pressoreceptors/drug effects/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reflex/drug effects
MH  - Somatostatin/administration & dosage/antagonists & inhibitors/*pharmacology
MH  - Time Factors
MH  - Virulence Factors, Bordetella/administration & dosage/*pharmacology
EDAT- 1992/01/06 00:00
MHDA- 1992/01/06 00:01
CRDT- 1992/01/06 00:00
PHST- 1992/01/06 00:00 [pubmed]
PHST- 1992/01/06 00:01 [medline]
PHST- 1992/01/06 00:00 [entrez]
AID - 0304-3940(92)90532-C [pii]
AID - 10.1016/0304-3940(92)90532-c [doi]
PST - ppublish
SO  - Neurosci Lett. 1992 Jan 6;134(2):267-70. doi: 10.1016/0304-3940(92)90532-c.