PMID- 1351730
OWN - NLM
STAT- MEDLINE
DCOM- 19920730
LR  - 20181130
IS  - 0882-8245 (Print)
IS  - 0882-8245 (Linking)
VI  - 5
IP  - 1
DP  - 1992 Spring
TI  - CD8+ CD11+ suppressor cells in HIV-infected asymptomatic patients: effect on 
      HIV-specific cytotoxicity.
PG  - 15-25
AB  - CD3+CD8+CD11+ cells were present in the peripheral blood of patients infected 
      with asymptomatic human immunodeficiency virus (HIV) in higher percentage 
      (10-20%) than in normal individuals (3-5%) in this study. These cells, through 
      the release of soluble factors, significantly suppressed the effector phase of 
      anti-HIV cytotoxic activities, both human leukocyte antigen (HLA)-class I or 
      class II restricted, and nonrestricted. The effectors were CD8+CD11-, CD4+ T 
      cells, and CD16+ cells for HLA-class I, class II restricted, and nonrestricted 
      cytotoxicities, respectively. The soluble factors also inhibited natural killer 
      cell activity. Thus, this effect was neither HLA-restricted nor antigen-specific. 
      These CD3+CD8+CD11+ cells may be an important immunopathogenic factor in HIV 
      disease.
FAU - Kundu, S K
AU  - Kundu SK
AD  - Center for AIDS Research, Stanford University Medical Center, California.
FAU - Merigan, T C
AU  - Merigan TC
LA  - eng
GR  - AI-27666-05/AI/NIAID NIH HHS/United States
GR  - AI-27762-03/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Viral Immunol
JT  - Viral immunology
JID - 8801552
RN  - 0 (Antigens, CD)
RN  - 0 (CD11 Antigens)
RN  - 0 (CD8 Antigens)
RN  - 0 (Suppressor Factors, Immunologic)
SB  - IM
MH  - Antigens, CD/analysis
MH  - CD11 Antigens
MH  - CD8 Antigens/analysis
MH  - Cytotoxicity, Immunologic/drug effects
MH  - HIV/*immunology
MH  - HIV Infections/*immunology
MH  - Humans
MH  - Killer Cells, Natural/drug effects
MH  - Suppressor Factors, Immunologic/metabolism/pharmacology
MH  - T-Lymphocyte Subsets/*immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1089/vim.1992.5.15 [doi]
PST - ppublish
SO  - Viral Immunol. 1992 Spring;5(1):15-25. doi: 10.1089/vim.1992.5.15.