PMID- 1352132
OWN - NLM
STAT- MEDLINE
DCOM- 19920806
LR  - 20100324
IS  - 1102-4151 (Print)
IS  - 1102-4151 (Linking)
VI  - 158
IP  - 4
DP  - 1992 Apr
TI  - Morphology, DNA ploidy and allele losses on chromosome 11 in sporadic 
      hyperparathyroidism and that associated with multiple neoplasia, type 1.
PG  - 199-206
AB  - OBJECTIVE: To analyse different forms of hyperparathyroidism (for example, 
      sporadic and multiple endocrine neoplasia type 1 (MEN 1)) by histopathology, DNA 
      cytometry and by the presence of allele losses on chromosome 11, thereby 
      identifying common characteristics. MATERIAL: Enlarged glands from 26 patients 
      with hyperparathyroidism (23 sporadic and 3 MEN 1). Cytometric assessment was 
      made of 28 glands. RESULTS: Nine patients had multiple gland disease and 15 had 
      single gland disease (14 sporadic and 1 MEN 1). DNA cytometry showed that 18 (15 
      sporadic and all 3 MEN 1) were diploid, seven tetraploid, and two aneuploid. Two 
      glands from one sporadic case showed different ploidy patterns. Seven patients 
      with sporadic and all three with MEN 1 hyperparathyroidism had allele losses for 
      chromosome 11 in the analysed glands. CONCLUSION: There were no significant 
      differences in histopathological appearances, ploidy, or allele losses among 
      abnormal glands from a variety of forms of hyperparathyroidism.
FAU - Sandelin, K
AU  - Sandelin K
AD  - Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
FAU - Larsson, C
AU  - Larsson C
FAU - Falkmer, U G
AU  - Falkmer UG
FAU - Farnebo, L O
AU  - Farnebo LO
FAU - Grimelius, L
AU  - Grimelius L
FAU - Nordenskjold, M
AU  - Nordenskjold M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Surg
JT  - The European journal of surgery = Acta chirurgica
JID - 9105264
RN  - 0 (Genetic Markers)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Chromosomes, Human, Pair 11/*ultrastructure
MH  - DNA/*analysis/genetics
MH  - Diagnosis, Differential
MH  - Female
MH  - Flow Cytometry/methods
MH  - Genetic Markers
MH  - Genotype
MH  - Humans
MH  - Hyperparathyroidism/genetics/*pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/genetics/*pathology
MH  - Parathyroid Glands/pathology
MH  - Parathyroid Neoplasms/genetics/*pathology
MH  - *Ploidies
EDAT- 1992/04/01 00:00
MHDA- 1992/04/01 00:01
CRDT- 1992/04/01 00:00
PHST- 1992/04/01 00:00 [pubmed]
PHST- 1992/04/01 00:01 [medline]
PHST- 1992/04/01 00:00 [entrez]
PST - ppublish
SO  - Eur J Surg. 1992 Apr;158(4):199-206.